SPRED1 Protein (AA 1-444) (His tag)

Catalog No. ABIN7280801

Product Details

Target: SPRED1 (Sprouty-Related, EVH1 Domain Containing 1 (SPRED1))

Protein Type: Recombinant

Protein Characteristics: AA 1-444

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This SPRED1 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: MGSSHHHHHH SSGLVPRGSH MGSMSEETAT SDNDNSYARV RAVVMTRDDS SGGWLPLGGS GLSSVTVFKV PHQEENGCAD FFIRGERLRD KMVVLECMLK KDLIYNKVTP TFHHWKIDDK KFGLTFQSPA DARAFDRGIR RAIEDISQGC PESKNEAEGA DDLQANEEDS SSSLVKDHLF QQETVVTSEP YRSSNIRPSP FEDLNARRVY MQSQANQITF GQPGLDIQSR SMEYVQRQIS KECGSLKSQN RVPLKSIRHV SFQDEDEIVR INPRDILIRR YADYRHPDMW KNDLERDDAD SSIQFSKPDS KKSDYLYSCG DETKLSSPKD SVVFKTQPSS LKIKKSKRRK EDGERSRCVY CQERFNHEEN VRGKCQDAPD PIKRCIYQVS CMLCAESMLY HCMSDSEGDF SDPCSCDTSD DKFCLRWLAL VALSFIVPCM CCYVPLRMCH RCGEACGCCG GKHKAAG

Purity: > 80 % by SDS - PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Denatured

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl (  pH 8.0) containing 10 % glycerol

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Target Details

Target: SPRED1 (Sprouty-Related, EVH1 Domain Containing 1 (SPRED1))

Alternative Name: SPRED1 (SPRED1 Products)

Synonyms: fb14c08 Protein, fj51c03 Protein, zgc:85707 Protein, wu:fb14c08 Protein, wu:fj51c03 Protein, Xspred1 Protein, Xtspred1 Protein, 5730461F13Rik Protein, AL024345 Protein, AW047647 Protein, NFLS Protein, hSpred1 Protein, spred-1 Protein, sprouty-related, EVH1 domain containing 1 Protein, sprouty related EVH1 domain containing 1 Protein, sprouty related, EVH1 domain containing 1 Protein, sprouty related, EVH1 domain containing 1 L homeolog Protein, SPRED1 Protein, sprouty protein with EVH-1 domain 1, related sequence Protein, spred1 Protein, SPRED1 Protein, spred1.L Protein, Bm1_51610 Protein, Spred1 Protein

Background: SPRED1 is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. This protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). Recombinant human SPRED1 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Molecular Weight: 52.9 kDa (467aa)

NCBI Accession: NP_689807

UniProt: Q7Z699

Pathways: Positive Regulation of Response to DNA Damage Stimulus