PPM1A Products
(Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
Categories
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
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Featured PPM1A Categories
PPM1A Antibodies
High quality antibodies with extensive validation data.
PPM1A ELISA Kits
Reliable ELISA kits for a wide range of species.
PPM1A Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PPM1A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Monkey
Application
FACS, ELISA, WB
Validations
- (2)
- (5)
Cat. No.
ABIN969556
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
IF, IHC (p), PLA, ELISA, WB
Validations
- (5)
Cat. No.
ABIN519084
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
IF, WB
Validations
- (4)
Cat. No.
ABIN6146039
Quantity
100 μL
Datasheet
Datasheet
Recommended PPM1A ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6958947
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958948
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730765
Quantity
96 tests
Datasheet
Datasheet
Recommended PPM1A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7320335
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3086396
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3134251
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PPM1A products
: "Protein phosphatase magnesium-dependent 1A induces inflammation in rheumatoid arthritis." in: Biochemical and biophysical research communications, Vol. 522, Issue 3, pp. 731-735, (2020) (PubMed).: "The intracellular protein phosphatase magnesium-dependent 1A negatively regulates osteoclast commitment." in: Arthritis & rheumatology (Hoboken, N.J.), (2019) (PubMed).
: "NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction." in: The Journal of biological chemistry, Vol. 292, Issue 19, pp. 7866-7887, (2017) (PubMed).
: "Role of protein phosphatase magnesium-dependent 1A and anti-protein phosphatase magnesium-dependent 1A autoantibodies in ankylosing spondylitis." in: Arthritis & rheumatology (Hoboken, N.J.), Vol. 66, Issue 10, pp. 2793-803, (2014) (PubMed).
: "Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants." in: Biological psychiatry, Vol. 69, Issue 4, pp. 360-5, (2011) (PubMed).
: "PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation." in: Cellular signalling, Vol. 21, Issue 1, pp. 95-102, (2008) (PubMed).
: "PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling." in: Cell, Vol. 125, Issue 5, pp. 915-28, (2006) (PubMed).
: "Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway." in: The Journal of biological chemistry, Vol. 281, Issue 48, pp. 36526-32, (2006) (PubMed).
: "Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes." in: The Journal of biological chemistry, Vol. 279, Issue 21, pp. 22715-26, (2004) (PubMed).
: "Cell cycle regulation and p53 activation by protein phosphatase 2C alpha." in: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 14299-305, (2003) (PubMed).
Synonyms and alternative names related to PPM1A
protein phosphatase, Mg2+/Mn2+ dependent 1A (PPM1A), protein phosphatase 1A, magnesium dependent, alpha isoform (Ppm1a), protein phosphatase, Mg2+/Mn2+ dependent, 1A (Ppm1a), protein phosphatase, Mg2+/Mn2+ dependent 1A L homeolog (ppm1a.L), protein phosphatase, Mg2+/Mn2+ dependent 1A (Ppm1a), protein phosphatase, Mg2+/Mn2+ dependent, 1Aa (ppm1aa), 2310003C21Rik, 2900017D14Rik, AI427932, AU017636, MMPa-2, MPPa-1, PP2C-ALPHA, pp2c-alpha, Pp2c1, PP2CA, pp2ca, pp2ca2, PP2Calpha, pp2calphaProtein level used designations for PPM1A
- protein phosphatase 1A
- protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
- Mpp alpha
- PP2C-alpha
- protein phosphatase 2C isoform alpha
- protein phosphatase IA
- IA
- Protein phosphatase type 1A (formely 2C) Mg-dependent alpha isoform
- Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform
- protein phosphatase 1A, magnesium dependent, alpha isoform
- protein phosphatase 2C alpha
- protein phosphatase type 2C alpha 2
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