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Proteoglycan 4 Products

(Proteoglycan 4 (PRG4))
The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured Proteoglycan 4 Categories

Proteoglycan 4 Antibodies

High quality antibodies with extensive validation data.

Proteoglycan 4 ELISA Kits

Reliable ELISA kits for a wide range of species.

Proteoglycan 4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Proteoglycan 4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, ICC, IP
Validations
  • (4)
Cat. No. ABIN7436231
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN6244267
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN523617
Quantity 100 μg
Datasheet Datasheet

Recommended Proteoglycan 4 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
  • (1)
Cat. No. ABIN6958971
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969764
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962372
Quantity 96 tests
Datasheet Datasheet

Recommended Proteoglycan 4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1316188
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7423159
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7398845
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Proteoglycan 4 products

Toledo, Golden, Campos, Cuello, Sorrentino, Lewis, Varki, Nizet, Smith, Esko: "Proteomic atlas of organ vasculopathies triggered by Staphylococcus aureus sepsis." in: Nature communications, Vol. 10, Issue 1, pp. 4656, (2019) (PubMed).

Clearfield, Xin, Yadav, Rowe, Wei: "Osteochondral Differentiation of Fluorescent Multireporter Cells on Zonally-Organized Biomaterials." in: Tissue engineering. Part A, (2018) (PubMed).

Ogawa, Matsumoto, Terabayashi, Kawashima, Takeuchi, Akiyama: "Association of lubricin concentration in synovial fluid and clinical status of osteoarthritic knee." in: Modern rheumatology, Vol. 27, Issue 3, pp. 489-492, (2016) (PubMed).

Roffi, Filardo, Assirelli, Cavallo, Cenacchi, Facchini, Grigolo, Kon, Mariani, Pratelli, Pulsatelli, Marcacci: "Does platelet-rich plasma freeze-thawing influence growth factor release and their effects on chondrocytes and synoviocytes?" in: BioMed research international, Vol. 2014, pp. 692913, (2014) (PubMed).

Guo, Fang, Li, Ke, Deng, Meng, Li, Long: "Up-regulation of proteoglycan 4 in temporomandibular osteoarthritic synovial cells by hyaluronic acid." in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, (2014) (PubMed).

Shepard, Jeong, Maihle, OBrien, Dealy: "Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo." in: Arthritis research & therapy, Vol. 15, Issue 3, pp. R60, (2014) (PubMed).

Musumeci, Loreto, Carnazza, Cardile, Leonardi: "Acute injury affects lubricin expression in knee menisci: an immunohistochemical study." in: Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, Vol. 195, Issue 2, pp. 151-8, (2013) (PubMed).

Liu, Tefft, Roberts, Zhang, Ren, Li, Huang, Zhang, Phillips, Wu: "Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia." in: American journal of physiology. Heart and circulatory physiology, Vol. 303, Issue 12, pp. H1446-58, (2012) (PubMed).

Leonardi, Musumeci, Sicurezza, Loreto: "Lubricin in human temporomandibular joint disc: an immunohistochemical study." in: Archives of oral biology, Vol. 57, Issue 6, pp. 614-9, (2012) (PubMed).

Leonardi, Rusu, Loreto, Loreto, Musumeci: "Immunolocalization and expression of lubricin in the bilaminar zone of the human temporomandibular joint disc." in: Acta histochemica, Vol. 114, Issue 1, pp. 1-5, (2011) (PubMed).

Synonyms and alternative names related to Proteoglycan 4

proteoglycan 4 (PRG4), proteoglycan 4 (Prg4), proteoglycan 4b (prg4b), proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) (Prg4), bG174L6.2, CACP, DOL54, HAPO, JCAP, lubricin, MSF, prg4, PRG4, si:dkey-97o5.3, SZP, zgc:122988

Protein level used designations for Proteoglycan 4

  • articular superficial zone protein
  • bG174L6.2 (MSF: megakaryocyte stimulating factor )
  • lubricin
  • megakaryocyte stimulating factor
  • megakaryocyte-stimulating factor
  • superficial zone proteoglycan
  • MLL septin-like fusion
  • proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome)
  • proteoglycan 4
  • p53-responsive gene 4
  • proteoglycan 3
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