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anti-Mouse (Murine) RNF168 Antibodies:
anti-Human RNF168 Antibodies:
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The findings demonstrate that RNF168 couples PALB2-dependent homologous recombination to H2A ubiquitylation to promote DNA repair and preserve genome integrity.
RNF168, in complex with RAD6A (show ube2a Antibodies) or RAD6B (show UBE2B Antibodies), is activated in the DNA-damage-induced protein ubiquitination cascade.
Rnf168 is important for maintaining genomic integrity, and it cooperates with p53 (show TP53 Antibodies) in suppressing tumorigenesis.
We identified 85 overlapping deletions, of which six included the RPL35A (show RPL35A Antibodies) gene and all should be had Diamond-Blackfan anemia (DBA (show RPS19 Antibodies)).we sequenced the remaining RNF168 gene and examined her fibroblast culture for a DNA double strand break repair deficiency. These results were normal, indicating that the immunodeficiency is unlikely to result from a RNF168 deficiency.
Ubiquitin ligases RNF168, RNF169 (show RNF169 Antibodies), and RAD18 (show RAD18 Antibodies) specifically bind histone H2A Lys13/15-ubiquitylated nucleosomes. 53BP1 (show TP53BP1 Antibodies) chromatin recruitment may be activated by RNF168 and blocked by RNF169 (show RNF169 Antibodies) and RAD18 (show RAD18 Antibodies).
deregulated RNF168/53BP1 (show TP53BP1 Antibodies) pathway could promote tumorigenesis by selecting for a more robust, better stress-adapted cancer cell phenotype, through altered DNA repair, fueling genomic instability and tumor heterogeneity
Further mining of the UBE2U (show UBE2U Antibodies) interactome uncovered its cognate E3 RNF17 (show RNF17 Antibodies) as a novel factor that, via the radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties (RIDDLE) syndrome protein RNF168, enforces DNA damage responses.
The association of RNF168 with PML (show PML Antibodies) NBs (show NBN Antibodies) resulted in increased ubiquitylation.
Results reveal an important role of USP7 (show USP7 Antibodies) in regulating ubiquitin-dependent signaling via stabilization of RNF168.
CK2 (show CSNK2A1 Antibodies)/WIP1 (show PPM1D Antibodies)-mediated modulation of LSD1 (show KDM1A Antibodies) phosphorylation facilitates RNF168-dependent ubiquitination and recruitment of 53BP1 (show TP53BP1 Antibodies) to the DNA damage sites.
The ubiquitin ligase RNF168 is strictly dependent on the activity that UbK27 is required to promote chromatin ubiquitination following DNA damage.
Finding that RNF8 (show RNF8 Antibodies) is less abundant than RNF168 identifies RNF8 (show RNF8 Antibodies) as a rate-limiting determinant of focal repair complex assembly
This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome.
E3 ubiquitin-protein ligase RNF168
, ring fnger protein 168