Browse our CSE1L Proteins (CSE1L)

Full name:: CSE1 Chromosome Segregation 1-Like (Yeast) Proteins (CSE1L)

On www.antibodies-online.com are 4 CSE1 Chromosome Segregation 1-Like (Yeast) (CSE1L) Proteins from 3 different suppliers available. Additionally we are shipping CSE1L Antibodies (91) and CSE1L Kits (2) and many more products for this protein. A total of 102 CSE1L products are currently listed.

Synonyms:: 2610100P18Rik, AA407533, BcDNA:LD14270, Capts, Cas, CG13281, CSE1, CSE1L, dcas, DKFZp459E1929, Dmel\\CG13281, Exportin-2, l(2)k03902, xpo2

list all proteins	Gene Name	GeneID	UniProt
Mouse CSE1L	CSE1L	110750	Q9ERK4
	CSE1L	1434	P55060
Rat CSE1L	CSE1L	362273
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CSE1L Proteins (CSE1L) by Origin

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Relevant Pathways for CSE1L Proteins

Protein targeting to Nucleus

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More Proteins for CSE1L Interaction Partners

Fruit Fly (Drosophila melanogaster) CSE1 Chromosome Segregation 1-Like (Yeast) (CSE1L) interaction partners

an important role for Cas proteins in cell-cell adhesion signaling in development

Mouse (Murine) CSE1 Chromosome Segregation 1-Like (Yeast) (CSE1L) interaction partners

serum phospho-CSE1L is useful for early detecting the efficacy of targeted therapy in initial treatment.
CSE1L knockdown reduced Ras-induced metastasis of B16F10 melanoma cells in C57BL/ (show HRAS Proteins)6 mice. v-H-Ras expression altered the cellular trafficking of CSE1L and increased CSE1L secretion.
Serum cellular apoptosis susceptibility protein may have a role in progression of metastatic colorectal cancer
CSE1L/CAS has a role in proliferation and apoptosis [review]

Zebrafish CSE1 Chromosome Segregation 1-Like (Yeast) (CSE1L) interaction partners

Cse1l is a negative regulator of cystic fibrosis transmembrane conductance regulator (show CFTR Proteins)-dependent fluid secretion.

Human CSE1 Chromosome Segregation 1-Like (Yeast) (CSE1L) interaction partners

Our data suggest a previously unanticipated link between CAS and integrin beta1 signaling which correlates with an aggressive hepatocellular carcinoma phenotype.
CSE1L knockdown by shRNA inhibited protein, resulting in decreased cell proliferation, reduced colony formation in soft agar, and induction of apoptosis. CSE1L protein is expressed early and across all stages of colorectal carcinoma (CRC (show CALR Proteins)) development. shRNA knockdown of CSE1L was associated with inhibition of tumorigenesis in CRC (show CALR Proteins) cells. CSE1L may represent a potential target for treatment of CRC (show CALR Proteins).
Data suggest that CAS overexpression in thyroid carcinoma depends on the subtype and the disease stage. Our findings also indicate that CAS maintains papillary thyroid cell proliferation and survival.
There is a relationship between nuclear CSE1L overexpression and distant metastasis in breast cancer.
CAS plays contrasting roles in proliferation and apoptosis
hCAS/CSE1L is responsible for controlling the homologous recombinational repair activity by directly interacting with RAD51 (show RAD51 Proteins).
nuclear CSE1L is mainly non-phosphorylated CSE1L and is involved in gene regulation and cytoplasmic CSE1L is mainly phosphorylated CSE1L and is involved in cytoplasmic signaling regulation in melanocytic tumorigenesis.
These results indicate that CSE1L is associated with viability and apoptosis, cellular adhesion and invasion, thus implicating CSE1L in the progression of colorectal cancer.
The cellular apoptosis susceptibility/importin-alpha1 transport cycle is linked to X-linked inhibitor (XIAP (show XIAP Proteins)) and is required to maintain tumor cell survival in hepatocellular carcinoma.
CSE1L expression was significantly inhibited in RKO cells, causing cell cycle arrest in the G2/M and S phases and a delay in cell proliferation, as well as induction of apoptosis and an inhibition of colony growth capacity.

CSE1L Protein Profile

Protein Summary

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with CSE1L

CAS/CSE1 segregation protein (Cas)
chromosome segregation 1 like (CSE1L)
exportin-2 (LOC100542094)
chromosome segregation 1 like (cse1l)
chromosome segregation 1-like (S. cerevisiae) (Cse1l)
CSE1 chromosome segregation 1-like (yeast) (cse1l)
CSE1 chromosome segregation 1-like L homeolog (cse1l.L)
chromosome segregation 1 like (Cse1l)

2610100P18Rik protein
AA407533 protein
BcDNA:LD14270 protein
Capts protein
Cas protein
CG13281 protein
CSE1 protein
CSE1L protein
dcas protein
DKFZp459E1929 protein
Dmel\\CG13281 protein
Exportin-2 protein
l(2)k03902 protein
xpo2 protein

Protein level used designations for CSE1L

CG13281-PA , Cas-PA , Importin-alpha re-exporter , CSE1 chromosome segregation 1-like (yeast) , CSE1 chromosome segregation 1-like protein , CSE1 chromosome segregation 1-like , exportin-2-like , chromosome segregation 1-like protein , exp2 , exportin-2 , importin-alpha re-exporter , bao , baobab , cellular apoptosis susceptibilit , cellular apoptosis susceptibility , exportin 2 , cellular apoptosis susceptibility protein

GENE ID	SPECIES
35016	Drosophila melanogaster
458318	Pan troglodytes
704301	Macaca mulatta
100023432	Monodelphis domestica
100056886	Equus caballus
100075465	Ornithorhynchus anatinus
100172855	Pongo abelii
100393152	Callithrix jacchus
100483977	Ailuropoda melanoleuca
100542094	Meleagris gallopavo
100559262	Anolis carolinensis
110750	Mus musculus
30707	Danio rerio
444464	Xenopus laevis
1434	Homo sapiens
419212	Gallus gallus
518622	Bos taurus
362273	Rattus norvegicus
477257	Canis lupus familiaris

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