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Cow (Bovine) Polyclonal IPO11 Primary Antibody for WB - ABIN252450
Hwang, McCool, Wan, Wuerzberger-Davis, Young, Choi, Cingolani, Weaver, Miyamoto: IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation. in The Journal of biological chemistry 2015
High IPO11 expression is associated with migration, invasion, and progression of bladder cancer.
IPO11 copy number amplification and importin-11 overexpression are promising biomarkers for predicting the progression and poor prognosis of patients with NMIBC.
IPO11 provides protection in another way, the researchers found. The transport receptor also shuttles UBE2E1, an enzyme necessary for PTEN ubiquitination, into the nucleus. Thanks to IPO11, normal cells keep all of their UBE2E1 in the nucleus, allowing PTEN to continue functioning in the cytoplasm. In cells lacking IPO11, UBE2E1 remains in the cytoplasm and promotes the destruction of PTEN.
IPO11-HTR1A is a significant risk gene region for attention deficit hyperactivity disorder in Caucasians.
Data indicate that ubiquitin-conjugating enzyme UBE2E3 and importin 11 (Imp-11)promote the nuclear accumulation and activity of transcription factor NF-E2 (Nrf2) by restricting the transcription factor from partitioning to the mitochondria
Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1\; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000
, Ran binding protein 11
, ran-binding protein 11