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anti-Human KPNA7 Antibodies:
anti-Cow (Bovine) KPNA7 Antibodies:
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KPNA7 has a critical role in the regulation of mitosis through the proper organization of the mitotic spindle and acts in the maintenance of the nuclear envelope structure and nuclear morphology.
KPNA7 binding and nuclear transfer was validated for two proteins, MVP and ZNF414. MVP and ZNF414 have a key role in the regulation of pancreatic cancer cell growth.
Our data show that compound heterozygous mutations in KPNA7 are associated with a human neurodevelopmental disease, and provide the first example of a human disease associated with mutation of a nuclear transport receptor.
Bel1 fragment with residues 215-223, which bears the NLS, interacts with KPNA1, KPNA6, and KPNA7.
KPNA7 silencing inhibits the malignant properties of pancreatic cancer cells in vitro and thereby provide the first evidence on the functional role for KPNA7 in human cancer.
Bovine ephemeral fever rhabdovirus alpha1 protein binds bovin importin beta1 and importin 7.
KPNA7: mRNA specifically expressed in ovary & mature oocyte; protein high in oocyte & early embryo but low in blastocyst; strong binding affinity for nucleoplasmin 2; KPNA7 knockdown in early embryos decreases embryo development; DNA & AA sequences
a decreased H7N9 influenza A virus polymerase activity when importin-alpha7 was silenced by siRNA, is reported.
a novel importin alpha family member with distinct subcellular localization and nuclear localization signal binding characteristics
knocking out of Kpna7 induced abnormalities of gene expression (dppa2, dppa4, and piwil2) and epigenetic modifications (down-regulation of histone H3K27me3). Biochemical analysis showed that KPNA7 interacts with KPNB1 (importin-beta1).
KPNA7 may transport intracellular proteins that possess unique nuclear localisation signals.
Functions in nuclear protein import (By similarity).
karyopherin alpha 7 (importin alpha 8)
, importin subunit alpha-8-like
, importin subunit alpha-8
, karyopherin 7
, karyopherin subunit alpha-7
, importin alpha 8
, importin alpha 2
, nuclear transport receptor
, Karyopherin subunit alpha-7