KPNA7 antibody (N-Term)

Catalog No. ABIN6991419

Product Details anti-KPNA7 Antibody

Target: KPNA7 (Karyopherin alpha 7 (Importin alpha 8) (KPNA7))

Binding Specificity: AA 40-90, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KPNA7 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: KPNA7 antibody is human specific. KPNA7 antibody is predicted to not cross-react with other Importin alpha family members.

Purification: KPNA7 Antibody is affinity chromatography purified via peptide column.

Immunogen: KPNA7 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human KPNA7. The immunogen is located within amino acids 40 - 90 of KPNA7.

Isotype: IgG

Application Details

Application Notes: KPNA7 antibody can be used for detection of KPNA7 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: KPNA7 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: KPNA7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for KPNA7

Target: KPNA7 (Karyopherin alpha 7 (Importin alpha 8) (KPNA7))

Alternative Name: KPNA7 (KPNA7 Products)

Synonyms: KPNA7 antibody, AW146299 antibody, Gm1055 antibody, karyopherin subunit alpha 7 antibody, karyopherin alpha 7 (importin alpha 8) antibody, KPNA7 antibody, kpna7 antibody, Kpna7 antibody

Background: KPNA7 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA7 is most closely related to KPNA2, but unlike KPNA2, KPNA7 primarily localizes to the nucleus. It has been suggested that KPNA7 may play a role in the transport of essential nuclear proteins required for early embryogenesis.

Gene ID: 402569

NCBI Accession: NP_001139187

UniProt: A9QM74

Pathways: Protein targeting to Nucleus