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These results showed that BLM enters the nucleus via the importin beta1, RanGDP and NTF2 dependent pathway, demonstrating for the first time the nuclear trafficking mechanism of a DNA helicase.
Binding of Ran to NTF2 is required for NTF2 to inhibit nuclear expansion and import of large cargo molecules.
Nucleocytoplasmic translocation of NTF2 is regulated in mammalian cells.
Data suggest actin accumulation in senescent cells is due to the failure of RanGTP restoration with ATP deficiency and NTF2 accumulation, resulting in decreased actin export via Exp6 inactivation.
A nuclear pore binding site was studied on a mutated NTF2 protein.
Results report that NTF2 and Ran control nuclear import of the filamentous actin capping protein CapG.
NTF2 is a potential mediator of retinal vasculature integrity.
The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.
, placental protein 15
, nuclear transport factor 2
, nuclear transport factor 2 L homeolog