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the data presented here suggest that CEA (show CEACAM5 Proteins) promoter-targeted exogenous RPL23 (show RPL17 Proteins) expression could be of therapeutic value against human colorectal carcinoma that retains wt-p53 (show TP53 Proteins).
the data presented here demonstrate that co-transduction of RPL23 (show RPL17 Proteins) enhances the therapeutic efficacy of adenoviral-mediated p53 (show TP53 Proteins) gene transfer in models of human gastric cancer and support the use of this strategy for cancer treatment.
L23 is a novel oncogene (show RAB1A Proteins) in the squamous cell carcinoma of the head and neck
Increased RPL23 (show RPL17 Proteins) expression is found in patients with higher-risk myelodysplastic syndrome (MDS (show PAFAH1B1 Proteins)) than in patients with lower-risk disease.
either RPS13 (show RPS13 Proteins) or RPL23 (show RPL17 Proteins) can promote MDR in gastric cancer cells by suppressing drug-induced apoptosis, and RPL23 (show RPL17 Proteins) may also promote MDR in gastric cancer cells through regulation of glutathione S-transferase (show GSTa2 Proteins)-mediated drug-detoxifying system
the MDM2 (show MDM2 Proteins)-L5-L11 (show RPL11 Proteins)-L23 complex functions to inhibit MDM2 (show MDM2 Proteins)-mediated p53 (show TP53 Proteins) ubiquitination and thus activates p53 (show TP53 Proteins)
These results reveal that ribosomal protein L23 is another regulator of the p53 (show TP53 Proteins)-MDM2 (show MDM2 Proteins) feedback regulation involved in cell growth.
Data show that, when overexpressed, ribosomal protein L23 inhibits HDM2-induced p53 (show TP53 Proteins) polyubiquitination and degradation and causes a p53 (show TP53 Proteins)-dependent cell cycle arrest.
The ribosomal protein L23 is a negative regulator of Miz1 (show ZBTB17 Proteins)-dependent transactivation.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae\; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
60S ribosomal protein L17
, 60S ribosomal protein L23
, ribosomal protein L17
, amino acid starvation-induced protein
, ribosomal protein L17A
, ribosomal protein L23
, ribosomal protein L23 L homeolog