Interleukin 1 Family Member 9 (IL1F9) (AA 13-164) (Active) protein (DYKDDDDK Tag)

Details for Product No. ABIN1344114
Protein Name
Protein Characteristics
AA 13-164
7
3
2
2
1
1
1
1
1
Origin
Mouse (Murine)
27
6
2
Source
Escherichia coli (E. coli)
33
1
1
Protein Type
Recombinant
Biological Activity
Active
Purification tag / Conjugate
DYKDDDDK Tag
Application
SDS-PAGE (SDS)
Options
Cross-Reactivity Mouse (Murine)
Characteristics Mouse IL-36gamma (aa Gly13-Ser164) is fused at the C-terminus to a FLAG®-tag.
Purity >95 % (SDS-PAGE)
Endotoxin Level <0.01EU/μg purified protein (LAL test, Lonza).
Protein Name
Background IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
Molecular Weight ~17kDa
UniProt Q8R460
Application Notes Optimal working dilution should be determined by the investigator.
Comment

Induces secretion of IL-6 in BMDCs.

Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute with 100 μL sterile water.
Concentration 0.1 mg/mL
Buffer Lyophilized. Contains PBS.
Storage 4 °C,-20 °C
Storage Comment Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.
Expiry Date 6 months