Clusterin Protein (CLU) (AA 22-448, Nuclear) (His tag)
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- Target See all Clusterin (CLU) Proteins
- Clusterin (CLU)
- Protein Type
- Recombinant
- Protein Characteristics
- Nuclear, AA 22-448
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Origin
- Mouse
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Clusterin protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Purpose
- Clusterin (nuclear form) (mouse) (rec.) (His)
- Cross-Reactivity
- Mouse
- Characteristics
- Mouse nuclear clusterin (aa 22-448) is fused at the C-terminus to a His-tag.
- Purity
- >90 % (SDS-PAGE)
- Sterility
- Sterile filtered
- Endotoxin Level
- <1EU/μg purified protein (LAL test).
- Top Product
- Discover our top product CLU Protein
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Clusterin (CLU) (AA 23-449) protein (His tag)
CLU Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Clusterin (CLU) (AA 22-448) protein (His tag)CLU Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Clusterin (CLU) (AA 184-293) protein (His-IF2DI Tag)CLU Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Clusterin (CLU) (AA 402-501) protein (GST tag)CLU Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- 0.2μm-filtered solution in 55 mM TRIS-Cl, pH 8.2, containing 150 mM NaCl.
- Handling Advice
- After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
- Expiry Date
- 6 months
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- Target
- Clusterin (CLU)
- Alternative Name
- Clusterin (CLU Products)
- Background
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TRPM-2, Apolipoprotein J, APO-J, CLI, CLU, SGP-2
Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80- kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.
- Molecular Weight
- ~45kDa (SDS-PAGE)
- UniProt
- Q549A5
- Pathways
- Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
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