AKR1A1 Protein (AA 1-325) (GST tag)

Catalog No. ABIN1344742

Product Details

Target: AKR1A1 (Aldo-Keto Reductase Family 1, Member A1 (Aldehyde Reductase) (AKR1A1))

Protein Type: Recombinant

Protein Characteristics: AA 1-325

Origin: Human

Source: Wheat germ

Purification tag / Conjugate: This AKR1A1 protein is labelled with GST tag.

Application: ELISA, Western Blotting (WB), Antibody Array (AA), Affinity Purification (AP)

Purpose: AKR1A1 (Human) Recombinant Protein (P01)

Sequence: MAASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY GNEPEIGEAL KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTICYDSTHY KETWKALEAL VAKGLVQALG LSNFNSRQID DILSVASVRP AVLQVECHPY LAQNELIAHC QARGLEVTAY SPLGSSDRAW RDPDEPVLLE EPVVLALAEK YGRSPAQILL RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV PMLTVDGKRV PRDAGHPLYP FNDPY

Characteristics: Human AKR1A1 full-length ORF ( AAH00670, 1 a.a. - 325 a.a.) recombinant protein with GST-tag at N-terminal.

Purification: in vitro wheat germ expression system

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Preparation method: in vitro, wheat germ expression system
Product Quality tested by: 12.5% SDS-PAGE Stained with Coomassie Blue.

Restrictions: For Research Use only

Handling

Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH =8.0 in the elution buffer.

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -80 °C

Storage Comment: Best use within three months from the date of receipt of this protein.

References

Atsriku, Hoffmann, Moghaddam, Kumar, Surapaneni: "In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism." in: Xenobiotica; the fate of foreign compounds in biological systems, Vol. 45, Issue 6, pp. 465-80, (2015) (PubMed).

Kassner, Huse, Martin, Gödtel-Armbrust, Metzger, Meineke, Brockmöller, Klein, Zanger, Maser, Wojnowski: "Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 36, Issue 10, pp. 2113-20, (2008) (PubMed).

Target Details

Target: AKR1A1 (Aldo-Keto Reductase Family 1, Member A1 (Aldehyde Reductase) (AKR1A1))

Alternative Name: AKR1A1 (AKR1A1 Products)

Background: Full Gene Name: aldo-keto reductase family 1, member A1 (aldehyde reductase)
Synonyms: ALDR1,ALR,ARM,DD3,MGC12529,MGC1380

Gene ID: 10327

Pathways: Monocarboxylic Acid Catabolic Process