AKR1A1 Protein (His tag)

Catalog No. ABIN7317529

Product Details

Target: AKR1A1 (Aldo-Keto Reductase Family 1, Member A1 (Aldehyde Reductase) (AKR1A1))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This AKR1A1 protein is labelled with His tag.

Purpose: Recombinant Human AKR1A1 Protein (His Tag)

Sequence: Met 1-Tyr 325

Characteristics: A DNA sequence encoding the human AKR1A1 (P14550) (Met 1-Tyr 325) was expressed, with a polyhistidine tag at the N-terminus.

Purity: > 90 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.5

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: AKR1A1 (Aldo-Keto Reductase Family 1, Member A1 (Aldehyde Reductase) (AKR1A1))

Alternative Name: AKR1A1 (AKR1A1 Products)

Synonyms: akr1a1 Protein, zgc:100940 Protein, aldr1 Protein, alr Protein, arm Protein, dd3 Protein, AKR1A1 Protein, zgc:110225 Protein, ALDR1 Protein, ALR Protein, ARM Protein, DD3 Protein, Akr1a4 Protein, 2610201A18Rik Protein, ALR1 Protein, Alr Protein, aldo-keto reductase family 1, member A1a (aldehyde reductase) Protein, aldo-keto reductase family 1, member A1 (aldehyde reductase) Protein, aldo-keto reductase family 1 member A1 Protein, aldo-keto reductase family 1, member A1b (aldehyde reductase) Protein, aldehyde reductase Protein, aldo-keto reductase family 1, member A1 (aldehyde reductase) L homeolog Protein, akr1a1a Protein, akr1a1 Protein, AKR1A1 Protein, akr1a1b Protein, Akr1a1 Protein, akr1a1.L Protein

Background:

Background: Aldehyde reductase (AKR1A1) is a member of the aldo-keto reductase superfamily, which consists of more than 40 known enzymes and proteins that includes variety of monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase. Aldehyde reductase has wide substrate specificities for carbonyl compounds. These enzymes are implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Aldehyde reductase possess a structure with a beta-alpha-beta fold which contains a novel NADP-binding motif. The binding site is located in a large, deep, elliptical pocket in the C-terminal end of the beta sheet, the substrate being bound in an extended conformation. This binding is more similar to FAD- than to NAD(P)-binding oxidoreductases. AKR1A1 is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue.

Synonym: ALDR1,ALR,ARM,DD3,HEL-S-6

Molecular Weight: 39 kDa

UniProt: P14550

Pathways: Monocarboxylic Acid Catabolic Process