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Interferon, alpha 4 (IFNa4) (AA 24-189) protein (His tag) Protein

IFNa4 Origin: Human Source: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN1880639
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  • Protein Name
    Protein Type
    Recombinant
    Protein Characteristics
    AA 24-189
    Origin
    Human
    Source
    Human Cells
    Purification tag / Conjugate
    This IFNA4 protein is labelled with His tag.
    Purpose
    Recombinant Human Interferon α-4/IFNA4 (C-6His)
    Sequence
    CDLPQTHSLG NRRALILLAQ MGRISHFSCL KDRHDFGFPE EEFDGHQFQK TQAISVLHEM IQQTFNLFST EDSSAAWEQS LLEKFSTELY QQLNDLEACV IQEVGVEETP LMNEDSILAV RKYFQRITLY LTEKKYSPCA WEVVRAEIMR SLSFSTNLQK RLRRKDVDHH HHHH
    Characteristics
    Recombinant Human Interferon alpha-4/IFNA4 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Cys24-Asp189) of Human IFNA4 fused with a polyhistidine tag at the C-terminus.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Sterility
    0.2 μm filtered
    Endotoxin Level
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
  • Protein Name
    Sub Type
    Fusionprotein
    Background
    Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow for communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. They are typically divided among three IFN classes: Type I, Type II and Type III. IFNA4 is a secreted protein and produced by macrophages. Two variants of IFNA4 (IFNA4a and IFNA4b) are known, which differ from each other by changes in their coding regions at nucleotide positions 220 and 410 .
    Alternative Names: Interferon alpha-4(IFNA4), also known as Interferon alpha-4B, Interferon alpha-76 and Interferon alpha-M1, belongs to the alpha/beta interferon family.
    Molecular Weight
    20.4 kDa
    UniProt
    P05014
    Pathways
    JAK-STAT Signaling, Hepatitis C
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.2.
    Handling Advice
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Storage
    4 °C/-20 °C/-80 °C
    Storage Comment
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Expiry Date
    3 months
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