TNFRSF1A Protein (AA 50-201)
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- Target See all TNFRSF1A Proteins
- TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 50-201
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Origin
- Human
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Source
- CHO Cells
- Characteristics
- ED50 < 50 ng/mL, measured in a cell proliferation assay using 929 cells in the presence of 1 ng/mL human TNF-a.
- Purity
- > 95 % as analyzed by SDS-PAGE.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product TNFRSF1A Protein
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Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 30-211) protein (His tag)
TNFRSF1A Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 30-211) protein (Fc Tag)TNFRSF1A Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 30-211) protein (His tag)TNFRSF1A Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 22-211) protein (His-DYKDDDDK-Strep II Tag)TNFRSF1A Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) proteinTNFRSF1A Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 22-212) protein (His tag)TNFRSF1A Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 22-211) protein (His tag)TNFRSF1A Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % by SDS - PAGE SDS
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 31-130) protein (GST tag)TNFRSF1A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (Active) protein (His tag)TNFRSF1A Origin: Mouse Host: HEK-293 Cells Recombinant > 96 % as determined by SDS-PAGE Active
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 1-455) protein (GST tag)TNFRSF1A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant Human TNF Receptor Type I remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human TNF Receptor Type I should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
- Expiry Date
- 6 months
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- Target
- TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))
- Alternative Name
- TNF Receptor Type I (TNFRSF1A Products)
- Background
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TNF Receptor Type I, is also known as TNF R-p55/p60 and TNFRSF1A. It is a type I transmembrane protein member of the TNF receptor superfamily. It is expressed in most cell types. Binding of either TNF-alpha or TNF-beta to TNF-R1 initiates a signal transduction pathway that results in the activation of the transcription factor NF-kappaB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells, induce apoptosis. TNF-R1 is essential for proper development of lymph node germinal centers and Peyer's patches and for combating intracellular pathogens such as Listeria. It is stored in the Golgi and translocates to the cell surface following proinflammatory stimuli.
Synonyms: Soluble Tumor Necrosis Factor type I, TNFRSF1A, TNFAR, TNF-R55, TNFR60, p55, CD120a - Molecular Weight
- 28-35 kDa, observed by reducing SDS-PAGE.
- UniProt
- P19438
- Pathways
- NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Hepatitis C, Ubiquitin Proteasome Pathway
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