MYD88 Protein (AA 176-280) (His tag,Strep II tag)
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- Target See all MYD88 Proteins
- MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 176-280
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This MYD88 protein is labelled with His tag,Strep II tag.
- Application
- Western Blotting (WB), ELISA, Mass Spectrometry (MS)
- Purity
- ~95 %
- Top Product
- Discover our top product MYD88 Protein
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Myeloid Differentiation Primary Response Gene (88) (MYD88) (AA 1-296) protein (His tag)
custom-made MYD88 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Myeloid Differentiation Primary Response Gene (88) (MYD88) (AA 1-296) protein (His tag)custom-made MYD88 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Myeloid Differentiation Primary Response Gene (88) (MYD88) (AA 31-130) protein (GST tag)MYD88 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Myeloid Differentiation Primary Response Gene (88) (MYD88) proteinMYD88 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % pure SDS
Myeloid Differentiation Primary Response Gene (88) (MYD88) (AA 1-296) protein (GST tag)MYD88 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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- Application Notes
- This recombinant protein can be used for WB, ELISA, MS.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 1X PBS containing 0.1 % SDS and 0.02 % NaN
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- Storage
- -80 °C
- Storage Comment
- Store in working aliquots at -70 °C.
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- Target
- MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))
- Alternative Name
- MyD88 (MYD88 Products)
- Background
- The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway (1). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-?B activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (2,3), which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.
- Molecular Weight
- 15 kDa (Calculated)
- Gene ID
- 4615
- OMIM
- 1814020
- UniProt
- Q99836
- Pathways
- NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades
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