CYLD Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2712747

Product Details

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 2

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This CYLD protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human CYLD (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

References

Thein, Tao-Cheng, Li, Bayer, Reese, Dosemeci: "CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density." in: PLoS ONE, Vol. 9, Issue 3, pp. e91312, (2014) (PubMed).

Target Details

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Alternative Name: Cyld (CYLD Products)

Synonyms: BRSS Protein, CDMT Protein, CYLD1 Protein, CYLDI Protein, EAC Protein, MFT Protein, MFT1 Protein, SBS Protein, TEM Protein, USPL2 Protein, 2010013M14Rik Protein, 2900009M21Rik Protein, C130039D01Rik Protein, mKIAA0849 Protein, cyld Protein, LRRGT00003 Protein, Rp1 Protein, Rp1h Protein, CYLD lysine 63 deubiquitinase Protein, cylindromatosis (turban tumor syndrome), a Protein, CYLD Protein, Cyld Protein, cylda Protein

Background: This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Molecular Weight: 106.9 kDa

NCBI Accession: NP_001035814

Pathways: Apoptosis, Activation of Innate immune Response