Neurturin (NRTN) (Active) Protein

Details for Product No. ABIN2727208
Protein Name
Escherichia coli (E. coli)
Protein Type
Biological Activity
Antibody Production (AbP), Functional Studies (Func), Protein Interaction (PI), Standard (STD)
Specificity Optimal preservation of protein structure, post-translational modifications and functions.
  • Recombinant human Neurturin protein expressed in E. coli.
  • Produced with end-sequenced ORF clone
  • Tested for bioactivity.
Purity > 95 % as determined by SDS-PAGE and Coomassie blue staining
Endotoxin Level Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).
Biological Activity Comment Human Neurturin at a concentration of 100 ng/ml will support the survival of 65% of newborn rat sympathetic neurons.
Protein Name
Background This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease.
Molecular Weight 11.8 kDa
NCBI Accession NP_004549
Application Notes Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays
Protein-protein interaction
In vitro biochemical assays and cell-based functional assays
Restrictions For Research Use only
Buffer Lyophilized from a 0.2 μM filtered solution of 20 mM phosphate buffer,100 mM NaCl, pH 7.2
Handling Advice Resuspend the protein in the desired concentration in proper buffer
Storage -80 °C
Storage Comment Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.