Neurturin (NRTN) (Active) Protein

Details for Product No. ABIN935696
Protein Name
Origin
Human
9
1
Source
Escherichia coli (E. coli)
8
2
Protein Type
Recombinant
Biological Activity
Active
Options
Sequence ARLGARPCGL RELEVRVSEL GLGYASDETV LFRYCAGACE AAARVYDLGL RRLRQRRRLR RERVRAQPCC RPTAYEDEVS FLDAHSRYHT VHELSARECA CV
Characteristics Purified recombinant Human Neurturin protein
Expression System: E.coli
Bioactivity: Human Neurturin at a concentration of 100 ng/mL will support the survival of 65 % of newborn rat sympathetic neurons.
Purity > 98 % pure
Endotoxin Level < 0.1 ng per µg (1 EU/µg).
Protein Name
Background Neurturin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Persephin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Neurturin signals through a multicomponent receptor system, composed of RET and one of four GFR alpha (alpha1-alpha4) receptors. Neurturin promotes the development and survival of sympathetic and sensory neurons by signaling through a receptor system composed of RET and GFRalpha2.
Alternative Names: NRTN protein, NTN protein
Application Notes Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions For Research Use only
Format Lyophilized
Buffer Supplied as a lyophilized powder.
Handling Advice Avoid repeated freeze/thaw cycles.
Storage RT/-20 °C
Storage Comment Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.