NLRP10 Protein (Myc-DYKDDDDK Tag)
(1 reference)-
- Target See all NLRP10 Proteins
- NLRP10 (NLR Family, Pyrin Domain Containing 10 (NLRP10))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This NLRP10 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human NLRP10 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product NLRP10 Protein
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NLR Family, Pyrin Domain Containing 10 (NLRP10) (AA 1-655) protein (His tag)
custom-made NLRP10 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
NLR Family, Pyrin Domain Containing 10 (NLRP10) (AA 1-673) protein (His tag)custom-made NLRP10 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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: "Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin-dependent degradation of NLRP10." in: Neuromolecular medicine, Vol. 16, Issue 1, pp. 205-15, (2014) (PubMed).
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: "Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin-dependent degradation of NLRP10." in: Neuromolecular medicine, Vol. 16, Issue 1, pp. 205-15, (2014) (PubMed).
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- Target
- NLRP10 (NLR Family, Pyrin Domain Containing 10 (NLRP10))
- Alternative Name
- Nlrp10 (NLRP10 Products)
- Background
- Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis.
- Molecular Weight
- 74.9 kDa
- NCBI Accession
- NP_789791
- Pathways
- Inflammasome
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