Norrie Disease (Pseudoglioma) (NDP) (AA 25-133) protein (His tag)

Details for Product No. ABIN5853193
Protein Name
Protein Characteristics
AA 25-133
3
1
1
1
Origin
Human
4
1
1
1
Source
Escherichia coli (E. coli)
2
2
2
1
Protein Type
Recombinant
Purification tag / Conjugate
His tag
Application
SDS-PAGE (SDS)
Options
Sequence MGSSHHHHHH SSGLVPRGSH MGSKTDSSFI MDSDPRRCMR HHYVDSISHP LYKCSSKMVL LARCEGHCSQ ASRSEPLVSF STVLKQPFRS SCHCCRPQTS KLKALRLRCS GGMRLTATYR YILSCHCEEC NS
Purity > 80 % by SDS - PAGE
Protein Name
Background Norrin precursor, also known as NDP, is a secreted regulatory protein. It activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. This protein plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. It may be involved in a pathway that regulates neural cell differentiation and proliferation. Recombinant human NDP protein, fused to His-tag at N-terminus, was expressed in E.coli.
Molecular Weight 14.8 kDa (132aa)
NCBI Accession NP_000257
UniProt Q00604
Pathways Sensory Perception of Sound
Application Notes Optimal working dilution should be determined by the investigator.
Comment

Denatured

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.4M urea, 10 % glycerol
Storage 4 °C,-20 °C,-80 °C
Storage Comment Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Supplier Images
Image no. 1 for Norrie Disease (Pseudoglioma) (NDP) (AA 25-133) protein (His tag) (ABIN5853193) Norrie Disease (Pseudoglioma) (NDP) (AA 25-133) protein (His tag)