LRP5 Protein (AA 644-1263) (Fc Tag)

Catalog No. ABIN6809855

Product Details

Target: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 644-1263

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This LRP5 protein is labelled with Fc Tag.

Sequence: AA 644-1263

Purity: >90 % as determined by SDS-PAGE.

Endotoxin Level: Less than 0.1 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

References

Pokharel, Mohanty, Mariasoosai, Miura, Maddison, Natesan, Bose: "Human beta defensin-3 mediated activation of β-catenin during human respiratory syncytial virus infection: interaction of HBD3 with LDL receptor-related protein 5." in: Frontiers in microbiology, Vol. 14, pp. 1186510, (2023) (PubMed).

Target Details

Target: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Alternative Name: LRP-5 (LRP5 Products)

Background: Low-density lipoprotein receptor-related protein 5(LRP-5) is also known as BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPTA1, VBCH2, LDL receptor related protein 5 and PCLD4. LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis-pseudoglioma (decrease in bone mass), while a gain-of-function mutation causes drastic increases in bone mass.

Molecular Weight: 96.6 kDa

NCBI Accession: NP_002326

Pathways: WNT Signaling, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation