LRP5 Protein (AA 644-1263) (Fc Tag)
-
- Target See all LRP5 Proteins
- LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 644-1263
-
Origin
- Human
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This LRP5 protein is labelled with Fc Tag.
- Sequence
- AA 644-1263
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 0.1 EU per μg by the LAL method.
- Top Product
- Discover our top product LRP5 Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
-
-
Human beta defensin-3 mediated activation of β-catenin during human respiratory syncytial virus infection: interaction of HBD3 with LDL receptor-related protein 5." in: Frontiers in microbiology, Vol. 14, pp. 1186510, (2023) (PubMed).
: "
-
Human beta defensin-3 mediated activation of β-catenin during human respiratory syncytial virus infection: interaction of HBD3 with LDL receptor-related protein 5." in: Frontiers in microbiology, Vol. 14, pp. 1186510, (2023) (PubMed).
-
- Target
- LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))
- Alternative Name
- LRP-5 (LRP5 Products)
- Background
- Low-density lipoprotein receptor-related protein 5(LRP-5) is also known as BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPTA1, VBCH2, LDL receptor related protein 5 and PCLD4. LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis-pseudoglioma (decrease in bone mass), while a gain-of-function mutation causes drastic increases in bone mass.
- Molecular Weight
- 96.6 kDa
- NCBI Accession
- NP_002326
- Pathways
- WNT Signaling, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation
-