GPC2 Protein (AA 22-556) (His tag)
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- Target See all GPC2 Proteins
- GPC2 (Glypican 2 (GPC2))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 22-556
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This GPC2 protein is labelled with His tag.
- Sequence
- AA 22-556
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product GPC2 Protein
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Glypican 2 (GPC2) (AA 22-556) protein (His tag)
GPC2 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Glypican 2 (GPC2) (AA 24-552) (Active) protein (His tag)GPC2 Origin: Rhesus Monkey Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Glypican 2 (GPC2) (AA 24-554) (Active) protein (His tag)GPC2 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Glypican 2 (GPC2) (AA 24-553) protein (Fc Tag)GPC2 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
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- Target
- GPC2 (Glypican 2 (GPC2))
- Alternative Name
- Glypican 2 (GPC2 Products)
- Background
- Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
- Molecular Weight
- 60.6 kDa
- NCBI Accession
- NP_766000
- Pathways
- Glycosaminoglycan Metabolic Process
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