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Glypican 2 (GPC2) (AA 22-556) (Active) protein (His tag) Protein

GPC2 Origin: Mouse Source: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Catalog No. ABIN6938871
$385.00
Plus shipping costs $45.00
100 μg ABIN6938871
100 μg ABIN6938871
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  • Protein Name
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 22-556
    Origin
    Mouse
    Source
    HEK-293 Cells
    Purification tag / Conjugate
    His tag
    Purity
    >95 % as determined by SDS-PAGE.
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Storage
    -20 °C
  • Protein Name
    Background
    Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
    Molecular Weight
    60.6 kDa
    NCBI Accession
    NP_766000
    Pathways
    Glycosaminoglycan Metabolic Process
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