Glypican 2 (GPC2) (AA 22-556) (Active) protein (His tag) Protein
GPC2
Origin: Mouse
Source: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
Catalog No. ABIN6938871
$385.00
Plus shipping costs $45.00
100 μg ABIN6938871
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- Protein Name
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 22-556
- Origin
- Mouse
- Source
- HEK-293 Cells
- Purification tag / Conjugate
- His tag
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
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- Protein Name
- Background
- Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
- Molecular Weight
- 60.6 kDa
- NCBI Accession
- NP_766000
- Pathways
- Glycosaminoglycan Metabolic Process
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