ICAM2 Protein (His tag)

Catalog No. ABIN7319578

Product Details

Target: ICAM2 (Intercellular Adhesion Molecule 2 (ICAM2))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This ICAM2 protein is labelled with His tag.

Purpose: Recombinant Human ICAM-2/CD102 Protein (His Tag)

Sequence: Lys25-Gln223

Characteristics: Recombinant Human ICAM-2 is produced by our Mammalian expression system and the target gene encoding Lys25-Gln223 is expressed with a 6His tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 2 mM CaCl2, 2 mM MgCl2, 5 % Threhalose, pH 7.2.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: ICAM2 (Intercellular Adhesion Molecule 2 (ICAM2))

Alternative Name: ICAM-2/CD102 (ICAM2 Products)

Background:

Background: ICAM-2 is a 55-65 kD transmembrane glycoprotein possessing 2 extracellular Ig domains, a single transmembrane domain, and a short 26-amino acid cytoplasmic domain. ICAM-2 is expressed on most leukocytes, and is strongly expressed on vascular endothelial cells. Interactions of ICAM-2 and the integrin receptors mediate cell adhesion in a wide range of lymphocyte, monocyte, natural killer cell, and granulocytewith other cells, and play important roles in many adhesion-dependent immune and inflammation responses, such as T cell aggregation, NK-cell cytotoxicity and migration, lymphocyte recirculation, etc. Serum levels of ICAM-2 correlated significantly with the inflammatory and course sequences of trichinosis in mice and had a similar relation with blood eosinophilia. So, estimation of ICAM-2 serum levels may prove useful in diagnosis of trichinosis recent infections, and in monitoring the prognosis and response to treatment.

Synonym: Intercellular Adhesion Molecule 2, ICAM-2, CD102, ICAM2

Molecular Weight: 23.13 kDa

UniProt: P13598