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SARS-CoV-2 NSP3 Protein

NSP3 Origin: SARS Coronavirus-2 (SARS-CoV-2) Host: Escherichia coli (E. coli) Recombinant >90 % as determined by SDS-PAGE
Catalog No. ABIN7321311
  • Target See all SARS-CoV-2 NSP3 (NSP3) Proteins
    SARS-CoV-2 NSP3 (NSP3) (SARS-CoV-2 Papain-Like Protease (NSP3))
    Protein Type
    Recombinant
    Origin
    SARS Coronavirus-2 (SARS-CoV-2)
    Source
    • 2
    Escherichia coli (E. coli)
    Purpose
    Recombinant SARS-CoV-2 NSP3 protein
    Sequence
    Glu1024-Gln1198
    Characteristics
    Recombinant SARS-CoV-2 NSP3 is produced by E.coli expression system and the target gene encoding Glu1024-Gln1198 is expressed with N-His Tag
    Purity
    >90 % as determined by SDS-PAGE
    Biological Activity Comment
    Test in progress
    Top Product
    Discover our top product NSP3 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    SARS-CoV-2 NSP3 (NSP3) (SARS-CoV-2 Papain-Like Protease (NSP3))
    Alternative Name
    SARS-CoV-2 NSP3 (NSP3 Products)
    Synonyms
    pp1ab Protein, ORF1a polyprotein;ORF1ab polyprotein Protein, ORF1ab Protein
    Target Type
    Viral Protein
    Background

    Background: The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.

    Synonym: nsp3,PL-PRO,Papain-like proteinase,X domain(Macro domain)

    Molecular Weight
    22.03kDa
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