SPINT2 Protein (His tag)
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- Target See all SPINT2 Proteins
- SPINT2 (serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2))
- Protein Type
- Recombinant
- Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This SPINT2 protein is labelled with His tag.
- Purpose
- Recombinant Mouse HAI-2/SPINT2 Protein (His Tag)
- Sequence
- Met 1-Lys 140
- Characteristics
- A DNA sequence encoding the extracellular domain (Met 1-Lys 140) of mouse SPINT2 (NP_001076017.1) precursor was expressed with a C-terminal polyhistidine tag.
- Purity
- > 90 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product SPINT2 Protein
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serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) protein (His tag)
SPINT2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % by SDS - PAGE SDS
serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) (AA 1-252) protein (GST tag)SPINT2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) protein (Myc-DYKDDDDK Tag)SPINT2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- SPINT2 (serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2))
- Alternative Name
- HAI-2/SPINT2 (SPINT2 Products)
- Background
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Background: Choanal (CA) and gastrointestinal atresias (GA) are an important feature of syndromic congenital sodium diarrhea (sCSD), a disorder recently associated with mutations in the gene for serine protease inhibitor type 2 (SPINT2). The SPINT2 gene is epigenetically silenced or downregulated in human cancers, altering the balance of HGF activation/inhibition ratio, which contributes to cancer development and progression. SPINT2 is a tumor suppressor gene that inhibits proteases implicated in cancer progression, like HGFA, hepsin and matriptase. Loss of SPINT2 expression in tumors has been associated with gene promoter hypermethylation. SPINT2 (serine peptidase inhibitor Kunitz type 2), a proteolytic inhibitor of hepatocyte growth factor activator (HGFA), which has a significant role in the suppression of the HGF-MET pathway and malignant melanoma progression.
Synonym: AL024025,C76321,HAI-2
- Molecular Weight
- 14 kDa
- NCBI Accession
- NP_001076017
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