EPH Receptor B1 Protein (EPHB1) (Fc Tag)

Catalog No. ABIN7319920

Product Details

Target: EPH Receptor B1 (EPHB1)

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This EPH Receptor B1 protein is labelled with Fc Tag.

Purpose: Recombinant Human Ephrin B Receptor 1/EphB1 (C-Fc)

Sequence: Met18-Pro540

Characteristics: Recombinant Human Ephrin Type-B Receptor 1 is produced by our Mammalian expression system and the target gene encoding Met18-Pro540 is expressed with a Fc tag at the C-terminus.

Purity: >95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Comment:

85-100 kDa

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: EPH Receptor B1 (EPHB1)

Alternative Name: EphB1 (EPHB1 Products)

Background:

Background: Ephrin Type-B Receptor 1 (EPHB1) is a single-pass type I membrane protein that belongs to the Ephrin-B family of receptor tyrosine kinases that is involved in embryonic nervous and vascular system development. EPHB1/EPHT2 contains two fibronectin type-III domains, one protein kinase domain and one SAM (sterile α motif) domain. EPHB1 could stimulate fibroblast motility on extracellular matrix in a kinase-dependent manner, which also correlated with its association with Grb7, an adaptor molecule implicated in the regulation of cell migration. It binds to ephrin-B1, ephrin-B2 and ephrin-B3. EPHB1 plays an important roles in diverse biological processes including nervous system development, angiogenesis, and neural synapsis formation and maturation and may be involved in cell-cell interactions in the nervous system.

Synonym: Ephrin Type-B Receptor 1, ELK, EPH Tyrosine Kinase 2, EPH-Like Kinase 6, EK6, hEK6, Neuronally-Expressed EPH, Related Tyrosine Kinase, NET, Tyrosine-Protein Kinase Receptor EPH-2, EPHB1, ELK, EPHT2, HEK6

Molecular Weight: 85.6 kDa

UniProt: P54762

Pathways: RTK Signaling