LIFR Protein (AA 45-833) (Fc Tag)

Catalog No. ABIN7275153

Product Details

Target: LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))

Protein Type: Recombinant

Protein Characteristics: AA 45-833

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This LIFR protein is labelled with Fc Tag.

Purpose: Human LIF R/CD118 Protein

Sequence: Gln45-Ser833

Characteristics: Recombinant Human LIF R/CD118 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gln45-Ser833.

Purity: > 95 % as determined by Tris-Bis PAGE

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Human LIF R, No Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Human LIF R, hFc Tag with the EC50 of 0.39μg/ml determined by ELISA. See testing image for detail.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as 0.22μm filtered solution in 20 mM Tris, 500 mM NaCL, 200 mM L-arginine, 5 mM DTT.

Preservative: Dithiothreitol (DTT)

Precaution of Use: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -80 °C

Storage Comment: Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))

Alternative Name: LIF R (LIFR Products)

Background: The leukemia inhibitory factor receptor (LIF-R) subunit is a component of cell-surface receptor complexes for the multifunctional cytokines, LIF, cardiotrophin-1, ciliary neurotrophic factor, and human oncostatin M. The structure of the human LIF-R gene is similar to that of the mouse gene. The transmembrane receptor is encoded by 19 exons.

Molecular Weight: 116.1 kDa. Due to glycosylation, the protein migrates to 120-160 kDa based on Tris-Bis PAGE result.

UniProt: P42702-1

Pathways: JAK-STAT Signaling, Growth Factor Binding