GIPR Protein (AA 22-138) (Fc Tag)
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- Target See all GIPR Proteins
- GIPR (Gastric Inhibitory Polypeptide Receptor (GIPR))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 22-138
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This GIPR protein is labelled with Fc Tag.
- Purpose
- Recombinant Human GIPR Protein with C-terminal human Fc tag
- Specificity
- GIPR (Arg22-Gln138) hFc (Glu99-Ala330)
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product GIPR Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- GIPR (Gastric Inhibitory Polypeptide Receptor (GIPR))
- Alternative Name
- GIPR (GIPR Products)
- Background
- This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
- Molecular Weight
- predicted molecular mass of 39.6 kDa after removal of the signal peptide. The apparent molecular mass of GIPR-hFc is 35-55 kDa due to glycosylation.
- UniProt
- P48546
- Pathways
- Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling
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