PINX1 Protein (AA 1-332) (His tag)

Catalog No. ABIN7560807

Product Details

Target: PINX1 (PIN2/TERF1 Interacting, Telomerase Inhibitor 1 (PINX1))

Protein Type: Recombinant

Protein Characteristics: AA 1-332

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This PINX1 protein is labelled with His tag.

Purpose: Custom-made recombinant Pinx1 Protein expressed in mammalian cells.

Sequence: MSMLAERRRK QKWTVDPRNT AWSNDDSKFG QKMLEKMGWS KGKGLGAQEQ GATEHIKVKV KNNHLGLGAT NNNEDNWIAH QDDFNQLLAA LNTCHGQETA DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSE TDLDCIFGKR RNKKLAQDGC SNSSADEVNT SLTTTTTTTS AFTIQEYFAK RMAQLKNKPQ ASAPGSDLSE TPVERKKGKK KNKEAADTDV ENSPQHKAKR HKKKKRVEAE RGPVAKKRDR AELQPGGPSE DECSDASVEA AEDCVQTPDI QDDVPKPKKR KAKKKLQRPE GVEIDATLDR APVKKKKKKV SR Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: PINX1 (PIN2/TERF1 Interacting, Telomerase Inhibitor 1 (PINX1))

Alternative Name: Pinx1 (PINX1 Products)

Background: PIN2/TERF1-interacting telomerase inhibitor 1 (67-11-3 protein) (LPTS1) (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (TRF1-interacting protein 1),FUNCTION: Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor (By similarity). {ECO:0000250}.

Molecular Weight: 37.2 kDa

UniProt: Q9CZX5