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Human Polyclonal CHP Primary Antibody for ICC, IF - ABIN443592
Kim, Lee, Jung, Bhattarai, Kwon: HIF-1α suppressing small molecule, LW6, inhibits cancer cell growth by binding to calcineurin b homologous protein 1. in Biochemical and biophysical research communications 2015
serum-independent activation of NHE1 by bound CHP2 is one of the key mechanisms for the maintenance of high pH(i) and the resistance to serum deprivation-induced cell death in malignantly transformed cells
CHP is important for pH(i)-dependent regulation of Na+/H+ exchanger 1 (NHE1) via tightly bound Ca2+ ions which serve as a crucial structural elements required for this role.
crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1
helix formation of the cytoplasmic region of NHE1 by calcineurin B homologous protein 1 is a prerequisite for generating the active form of NHE1
CHP2 has a role in tumorigenesis and as an activator of the calcineurin/NFAT signaling pathway
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
This study demonistrated that CHP1-mediated NHE1 biosynthetic maturation is required for Purkinje cell axon homeostasis.
This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity.
EF-hand calcium-binding domain-containing protein p22
, SLC9A1 binding protein
, calcineurin B homolog
, calcineurin B homologous protein 1
, calcineurin B-like protein
, calcineurin homologous protein
, calcineurin-like EF hand protein 1
, calcium binding protein P22
, calcium-binding protein CHP
, calcium-binding protein p22
, sid 470
, EF-hand Ca2+-binding protein p22
, calcium binding protein p22
, Calcium-binding protein CHP
, Calcium-binding protein p22