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anti-Human UCP3 Antibodies:
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Results here presented suggest that UCP (show UCP1 Antibodies) variability has different pleiotropic effects, by affecting both telomere length and glucose homeostasis, likely through an influence on energy metabolism and stress response
Cellular feedback regulation may occur between UCP2 (show UCP2 Antibodies)/UCP3 and ACE (show ACE Antibodies). Cellular UCP (show UCP1 Antibodies) regulation of sACE suggests a novel means of crosstalk between (and mutual regulation of) cellular and endocrine metabolism.
findings indicate that polymorphisms rs3813929 and rs1800849 from 5-HT2C and UCP3 genes were related to type 2 diabetes mellitus prevalence among the Brazilian obese women candidates for bariatric surgery.
In type 2 diabetics the combination of UCP3-55 CC and PPARgamma2 (show PPARG Antibodies) Pro12Ala genotypes is associated with significantly higher BMI than other PPARgamma2 (show PPARG Antibodies)-UCP3 genotype combinations, partly due to a reduced ability in lipids oxidation.
genetic association studies in population in Spain: Data suggest that responses among obese patients (weight loss and changes in insulin (show INS Antibodies) resistance/cardiovascular risk factors) to high protein/low carbohydrate reducing diet varies according to a genetic polymorphism in the promoter region of UCP3 (-55CT, rs1800849).
Combined, our data suggest functional significance of UCP-3 for H/R resistance
UCP1 (show UCP1 Antibodies) and UCP3 expression is associated with lipid and carbohydrate oxidation in patients submitted to bariatric surgery.
UCP3 overexpression limits keratinocyte proliferation and tumorigenesis through inhibition of Akt (show AKT1 Antibodies).
Children with UCP-3 -55 T/T genotype had a significantly lower adjusted metabolic rate than the C allele carriers.
A newly identified functional variant (rs1626521) in UCP-3 affects postprandial gastric functions and satiety and may contribute to weight gain and alter human mitochondrial function
Our findings, focusing on energy balance, provide a mechanistic understanding of the promising effect of early insulin (show INS Antibodies) initiation on lipotoxicity. Insulin (show INS Antibodies), by recovering UCP3 activity, alleviated energy surfeit and potentiated AMPK (show PRKAA1 Antibodies)-mediated lipid homeostasis in skeletal muscle cells following exposure to PA and in gastrocnemius of mice fed HFD.
UCP3 can be fully inhibited by all adenine nucleotides tested and IC50 increases with a decrease in PN-phosphorylation. Conserved arginines in the PN-binding pocket are involved in the inhibition of UCP1 (show UCP1 Antibodies) and UCP3 to different extents. Fatty acids compete only with ATP bound to UCP3. UCP3 has adapted to fulfill a different role and possibly another transport function in brown adipose tissue, vs highly homologous UCP1 (show UCP1 Antibodies).
Together the data show that both UCP1 (show UCP1 Antibodies) and UCP3 play essential and complementary roles in thermogenic responses in the mouse and suggest that UCP3-dependent thermogenesis is an under-appreciated mode of thermogenic energy dissipation.
The results indicate that mitochondrial UCP3 activity affects metabolism well beyond fatty acid oxidation, regulating biochemical pathways associated with amino acid metabolism and redox status.
Gene expression data revealed that 1, 4 or 8h of hypoxia results in temporal changes in various transcriptional genes regulating mitochondrial function and a time-dependent progressive increase in the expression of the mitochondrial uncoupling protein 3 (UCP-3) with concomitant changes in genes encoding sarcoplasmic reticulum calcium release proteins.
our study supports an essential role for UCP3 in modulating cardiac mCa2+ uptake via regulation of mCa1 single-channel activity.
Intriguingly, ectopic expression of constitutively active estrogen receptor alpha (show ESR1 Antibodies) decreased UCP3 level and increased cellular ATP content in differentiated myoblastic C2C12 cells. Overall, the present study suggests that estrogen plays a critical role in the regulation of energy expenditure and exercise endurance in female.
We found increased mRNA expression of PDK4 and UCP3, which are known to be upregulated after exercise and regulated by PGC-1alpha after lactate administration.
suggest that VD3/VDR (show CYP27B1 Antibodies) inhibits weight gain by activating UCP3 in the muscles.
the protective effect of PPARalpha (show PPARA Antibodies) activation against cardiac ischemia-reperfusion injury in terms of the expression of uncoupling protein (UCP (show UCP1 Antibodies)), was investigated.
The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain (show CAPN2 Antibodies)/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.
A study evaluating the relationships of uncoupling protein 2 (show UCP2 Antibodies) and 3 expression, SNP of mitochondrial DNA, and residual feed intake (RFI (show RNF34 Antibodies)) in Angus steers selected to have high or low RFI (show RNF34 Antibodies) is presented.
Association of pig UCP3 gene mutations and back fat thickness in the sixth and seventh rib.
Seven deletion polymorphisms were covered in introns of linkage genes of UCP2 (show UCP2 Antibodies) and UCP3, showing that UCPs have conservation and genetic reliability.
The in vivo data indicate that beta-adrenergic agonists may function in regulating UCP2 (show UCP2 Antibodies) and UCP3 expression in selected muscles.
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression\; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.
, mitochondrial uncoupling protein
, mitochondrial uncoupling protein 3
, uncoupling protein
, uncoupling protein 3 (mitochondrial, proton carrier)
, uncoupling protein UCP
, mitochondrial uncoupling protein 3-like
, solute carrier family 25 member 9
, UCP 3
, uncoupling protein 3, mitochondrial
, Uncoupling protein 3, mitochondrial