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anti-Human CAPZA1 Antibodies:
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Human Polyclonal CAPZA1 Primary Antibody for ELISA, WB - ABIN560165
Gemoll, Roblick, Szymczak, Braunschweig, Becker, Igl, Bruch, Ziegler, Hellman, Difilippantonio, Ried, Jörnvall, Auer, Habermann: HDAC2 and TXNL1 distinguish aneuploid from diploid colorectal cancers. in Cellular and molecular life sciences : CMLS 2011
Data show that CAPZA1 inhibits EMT in hepatocellular carcinoma (HCC cells by regulating actin cytoskeleton remodeling, thereby reducing the metastatic ability of the cells.
Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2.
mDia1 displaced from the barbed end by CapZ Actin Capping Protein can randomly slide along the actin filament and later return.
The present study suggests that CAPZA1 could be a marker of good prognosis in gastric cancer and shows that CAPZA1 is associated with decreased cancer cell migration and invasion.
CAPAZA1 is over expressed in malignant melanoma.
V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein
Cd2 antigen is linked to this protein via CMS and CIN85.
CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein
Damaging exercise induced the expression of capZalpha, MCIP1, CARP1, DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management.
Here, the authors discover that the C-terminal tail of Twinfilin harbors a capping protein-interacting (CPI) motif, identifying it as a novel CPI-motif protein. Twinfilin binds competitively with CARMIL to capping protein, protecting capping protein from barbed-end displacement by CARMIL.
These data further support the concept that the cardiac Z-disc protein is a regulator of myofilament function and intracellular signalling transduction.
Actin-capping protein is a novel regulator of microtubule stability that functions by antagonizing mDia1 activity toward actin filaments.
Mouse homolog of the adaptor protein CARMIL (mCARMIL) binds CP with high affinity and decreases its affinity for the barbed end
CapZ is an important component in anchoring PKC-beta(II) at the myofilaments, and for mediating the effects of PKC-beta(II) on myofilament function
actin-capping protein binds to the filament barbed end of myotrophin/V-1
Results demonstrate myofilament regulation by protein phosphatase type 1 alpha and CapZ, and support the concept that cardiac Z-discs are vital components in intracellular signalling.
CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments.
F-actin-capping protein subunit alpha-1
, capping protein (actin filament) muscle Z-line, alpha 1
, F-actin capping protein alpha-1 subunit
, scapping protein (actin filament) muscle Z-line, alpha 1b
, actin-capping protein (CapZ 36/32) alpha subunit
, beta-actinin subunit I
, capZ 36/32
, Cap Z
, capZ alpha-1
, capping protein alpha 1
, CapZ alpha-1
, actin-binding protein chain A
, nuclear actin-binding protein chain a
, CP alpha1
, F-actin capping protein alpha 1 subunit