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Human CCL21 Protein expressed in Baculovirus infected Insect Cells - ABIN2002927
Christopherson, Campbell, Hromas: Transgenic overexpression of the CC chemokine CCL21 disrupts T-cell migration. in Blood 2001
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the CCR7 (show CCR7 Proteins)/CCL21 signaling pathway leading to T lymphocyte migration on fibronectin (show FN1 Proteins) is a beta1 integrin-dependent pathway involving transient ERK1/2 phosphorylation, which is modulated by PLCgamma1 (show PLCG1 Proteins)
Data suggest that lymphotoxin (show LTB Proteins)-dependent and -independent regulation of CC chemokine ligand 21-b and -c plays a role in balancing the central and peripheral immune responses between lymphoid and nonlymphoid tissues.
CCL21 and, to a lesser extent, CCL19 (show CCL19 Proteins) play significant roles in the distinctive localization of marginal zone macrophages within the splenic marginal zone.
CCL21 and 5'-Nase may be involved in the interaction between infiltrating cells and lymphatic vessels to induce the functional changes of lymphatic endothelial cells during insulitic and diabetic development
CXCL9 (show CXCL9 Proteins) has a role in graft rejection in the absence of CCL19 (show CCL19 Proteins) and CCL21
T-cell defects in the nasal-associated lymphoid tissue of lymphotoxin (show LTB Proteins)(-/-) mice can be attributed to the impaired expression of CCL21.
alpha-GalCer-loaded dendritic cells expressing tumor-associated antigen along with SLC (show CCL21A Proteins) can stimulate multiple subsets of effector cells to induce a potent therapeutic effect against peritoneally disseminated tumor cells.
following Leishmania donovani infection of mice, the migration of splenic DC is regulated by the CCR7 (show CCR7 Proteins) ligands CCL19 (show CCL19 Proteins)/CCL21
Results suggest that CCR7 (show CCR7 Proteins)-positive fibrocytes infiltrate the kidney via CCL21-positive vessels, thereby contributing to the pathogenesis of renal fibrosis.
The presence of CCL21 during the in vitro stimulation of CD4 (show CD4 Proteins)+ T cells with anti-CD3 (show CD3E Proteins) plus anti-CD28 (show CD28 Proteins) significantly enhanced in vitro AICD induction of the restimulated T cells, partially through enhancing expression of Fas ligand (show FASL Proteins).
High CCL21 expression is associated with urinary bladder cancer metastasis.
Significant associations between the CCL21 rs2812378 G;A polymorphism and rheumatoid arthritis risk were observed in the total population, as well as in subgroup Caucasian population.
The research findings demonstrate for the first time that the chemokines CCL19 (show CCL19 Proteins), CCL21 and CCR7 (show CCR7 Proteins) play important roles in bone destruction by increasing osteoclast migration and resorption activity, and that has been linked to rheumatoid arthritis pathogenesis.
Low CCL21 expression was a potential independent adverse prognostic biomarker for overall survival and progression-free survival for metastatic renal cell carcinoma (show MOK Proteins) patients treated with targeted therapy.
The migratory index to the CCR7 (show CCR7 Proteins) ligands, CCL19 (show CCL19 Proteins) and CCL21, was higher in T-cells from donors whose recipients will develop GvHD.
these results demonstrated that CCL21/CCR7 may activate EMT in lung cancer cells via the ERK1/2 signaling pathway.
CCL21/CCR7 (show CCR7 Proteins) interaction was shown to allow NK cell adhesion to endothelial cells (ECs) and its reduction by hypoxia.
These data show that CCR7 (show CCR7 Proteins)-CCL19 (show CCL19 Proteins)/CCL21 axis facilitates retention CD4 (show CD4 Proteins)(+) T lymphocytes at the site of collateral artery remodeling, which is essential for effective arteriogenesis.
CCL21 correlated significantly with Bladder Pain Syndrome: gene expression in bladder biopsies of patients with Bladder Pain Syndrome was increased in the patients and correlated with clinical profiles.
CCL21/IL21 (show IL17C Proteins)-armed oncolytic adenovirus enhances antitumor activity against TERT (show TERT Proteins)-positive tumor cells.
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).
C-C motif chemokine 21b
, C-C motif chemokine 21c
, Small-inducible cytokine A21b
, beta chemokine exodus-2
, beta-chemokine exodus-2
, small inducible cytokine A21c
, small-inducible cytokine A21c
, thymus-derived chemotactic agent 4
, C-C motif chemokine 21
, Efficient Chemoattractant for Lymphocytes
, secondary lymphoid tissue chemokine
, small inducible cytokine subfamily A (Cys-Cys), member 21
, CC chemokine ligand 21
, putative CCL21 chemokine
, chemokine CCL21/6CKINE
, small-inducible cytokine A21
, small inducible cytokine A21
, chemokine (C-C motif) ligand 21
, chemokine (C-C motif) ligand 21b (serine)