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anti-Mouse (Murine) CCR7 Antibodies:
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Human Monoclonal CCR7 Primary Antibody for CyTOF, FACS - ABIN4899110
Lee, Fertig, Jin, Sukumar, Pandey, Popel: Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis. in Nature communications 2014
Show all 46 Pubmed References
Human Monoclonal CCR7 Primary Antibody for FACS - ABIN4895614
Santra, Tomaras, Warrier, Nicely, Liao, Pollara, Liu, Alam, Zhang, Cocklin, Shen, Duffy, Xia, Schutte, Pemble Iv, Dennison, Li, Chao, Vidnovic, Evans, Klein, Kumar, Robinson, Landucci, Forthal et al.: Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques. ... in PLoS pathogens 2015
Show all 34 Pubmed References
Human Monoclonal CCR7 Primary Antibody for FACS - ABIN4895619
Kaur, Sanford, Garry, Lang, Klumpp, Watanabe, Bronson, Lifson, Rosati, Pavlakis, Felber, Knipe, Desrosiers: Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus. in Virology 2006
Show all 34 Pubmed References
Human Polyclonal CCR7 Primary Antibody for ELISA, FACS - ABIN152135
Schweickart, Raport, Godiska, Byers, Eddy, Shows, Gray: Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2. in Genomics 1995
Show all 31 Pubmed References
Human Monoclonal CCR7 Primary Antibody for FACS - ABIN2689061
Kim, Pelus, White, Broxmeyer: Macrophage-inflammatory protein-3 beta/EBI1-ligand chemokine/CK beta-11, a CC chemokine, is a chemoattractant with a specificity for macrophage progenitors among myeloid progenitor cells. in Journal of immunology (Baltimore, Md. : 1950) 1998
Show all 10 Pubmed References
Human Monoclonal CCR7 Primary Antibody for FACS - ABIN2689059
Birkenbach, Josefsen, Yalamanchili, Lenoir, Kieff: Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. in Journal of virology 1993
Show all 9 Pubmed References
Human Monoclonal CCR7 Primary Antibody for FACS - ABIN2689060
Burgstahler, Kempkes, Steube, Lipp: Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2. in Biochemical and biophysical research communications 1995
Show all 8 Pubmed References
Human Monoclonal CCR7 Primary Antibody for FACS - ABIN4895610
Iyer, Gangadhara, Victor, Gomez, Basu, Hong, Labranche, Montefiori, Villinger, Moss, Amara: Codelivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CXCR5+ and CXCR5- CD4 T Cell Responses in Rhesus Macaques. in Journal of immunology (Baltimore, Md. : 1950) 2015
Show all 7 Pubmed References
Mouse (Murine) Monoclonal CCR7 Primary Antibody for CyTOF, FACS - ABIN4900691
Irino, Takeuchi, Matsuda, Saikawa, Kawakubo, Wada, Takahashi, Nakamura, Fukuda, Omori, Kitagawa: CC-Chemokine receptor CCR7: a key molecule for lymph node metastasis in esophageal squamous cell carcinoma. in BMC cancer 2014
Show all 5 Pubmed References
Human Polyclonal CCR7 Primary Antibody for FACS, IF (p) - ABIN674724
Ge, Li, Jiang, You, Liu, Zhong, Huang, Xing: Integration of nondegradable polystyrene and degradable gelatin in a core-sheath nanofibrous patch for pelvic reconstruction. in International journal of nanomedicine 2015
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Ccr7 functions during axis formation as a GPCR (show GPRC6A Antibodies) to inhibit beta-catenin (show CTNNB1 Antibodies), likely by promoting Ca(2 (show CA2 Antibodies)+) transients throughout the blastula.
Conditions for optimal dendritic cells guidance are perfectly provided by the CCL21 (show CCL21 Antibodies) gradients measured in vivo. Furthermore, CCR7 signal termination by the G-protein-coupled receptor kinase 6 (GRK6 (show GRK6 Antibodies)) is crucial for haptotactic but dispensable for chemotactic CCL21 (show CCL21 Antibodies) gradient sensing in vitro and confirm those observations in vivo.
CCR7 deficiency results in apoptosis of Sirpa (show SIRPA Antibodies)- dendritic cells, which is counterbalanced by expansion of immature Sirpa (show SIRPA Antibodies)+ dendritic cells that efficiently induce Treg generation.
These data show that CCR7-CCL19 (show CCL19 Antibodies)/CCL21 (show CCL21 Antibodies) axis facilitates retention CD4 (show CD4 Antibodies)(+) T lymphocytes at the site of collateral artery remodeling, which is essential for effective arteriogenesis.
Results demonstrated that the deletion of CCR7 significantly decreases levels of activated Notch1 (show NOTCH1 Antibodies), and provide evidence that crosstalk between CCR7 and Notch1 (show NOTCH1 Antibodies) promotes stemness in mammary cancer cells ultimately potentiating mammary tumor progression.
CCR7 deficiency lead to accumulation of CD8 (show CD8A Antibodies)+ adipose tissue leukocytes, which was further exacerbated by HFD feeding.
in the current study, we used interval mapping to validate a locus on Chr 15, named Ity8, linked to Salmonella resistance in AcB60 mice. Global gene expression analysis during infection identified AcB60-specific expression of genes involved in Ccr7 signaling, including downstream effector Mapk11 (mitogen-activated protein kinase 11 (show MAPK11 Antibodies)), located within the Ity8 interval, and representing a potential positional candidate gene
Taken together, these data suggest that CCR7 biases memory CD8 (show CD8A Antibodies) T cells toward IL-7 (show IL7 Antibodies)-dependent niches over IL-15 (show IL15 Antibodies)-dependent niches, which provides insight into the homeostatic regulation of different memory T-cell subsets.
Prominent mucosal immune responses in CCR7-deficient mice increased the efficiency of bacteria clearance from the FRT(female reproductive tract) while reducing tissue-associated inflammation and pathology; increased numbers of lymphocytes within the FRT result in pathogen clearance with reduced immune-mediated pathology
CCR7 is required to mount a robust immune response against enteropathogenic Y. pseudotuberculosis by promoting Th17-like responses in mesenteric lymph nodes.
CCR7 overexpression and RelB (show RELB Antibodies) knockdown (KD) in imDCs improve skin-graft survival in a murine skin-transplantation model. Transfection with Ad-CCR7 and RelB (show RELB Antibodies) KD in imDCs may be an effective approach inducing immune tolerance, thus being potentially valuable for inhibiting allograft rejection.
High CCR7 expression is associated with urinary bladder cancer metastasis.
these data indicate CCL19 (show CCL19 Antibodies)/CCR7 contributes to proliferation and invasion of ESCs (show NR2E3 Antibodies), which are conducive to the pathogenesis of endometriosis through activating PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway
The research findings demonstrate for the first time that the chemokines CCL19 (show CCL19 Antibodies), CCL21 (show CCL21 Antibodies) and CCR7 play important roles in bone destruction by increasing osteoclast migration and resorption activity, and that has been linked to rheumatoid arthritis pathogenesis.
CXCR4 (show CXCR4 Antibodies), CCR7, VEGF-C (show VEGFC Antibodies) and VEGF-D (show Figf Antibodies) expression might have synergistic effects on the lymph node metastasis in patients with cervical cancer.
the acute GvHD (aGvHD) patients received higher percentage of CD4 (show CD4 Antibodies)+CCR7+ T-cells in donor T-cells, whereas chronic GvHD (cGvHD) patients were transplanted with higher percentages of CD8 (show CD8A Antibodies)+CCR7+ T-cells. Functional experiments demonstrated that CCR7+ T-cells exhibited higher potential for activation than CCR7- T-cells did.
these results demonstrated that CCL21/CCR7 may activate EMT in lung cancer cells via the ERK1/2 signaling pathway.
CCL21 (show CCL21 Antibodies)/CCR7 interaction was shown to allow NK cell adhesion to endothelial cells (ECs) and its reduction by hypoxia.
Study shows that miR (show MLXIP Antibodies)-1275 can positively regulate CCR7 expression in squamous cell carcinoma of head and neck (SCCHN) with different mechanisms.
Study provide evidence that CCR7 mediates EMT (show ITK Antibodies) progress via AKT (show AKT1 Antibodies) pathway, which indicates that CCR7 has a key role in breast cancer progression.
Report an increased percentage of peripheral CCR7 T cells accompanied by endothelial dysfunction in patients with ankylosing spondylitis.
Fluorescent dye-labeled gammadelta T cells from afferent and efferent lymph lack CCR7 surface expression and display high levels of CD62L (show SELL Antibodies) compared with CD4 (show CD4 Antibodies) T cells, which do express CCR7.
CCR7 transcripts were minimally expressed in ex vivo and proliferating WC1(+)gammadelta T cells, a unique cell population with proinflammatory characteristics
the pattern of expression of CCR7 in different populations of porcine lymphocytes appears to be similar to that of human, highlighting the value of the pig as a useful animal model for biomedical studies.
Pre-translntation of sertli cell CCR7 significantly suppresses lymphocyte proliferation and prolongs allogeneic skin graft survival.
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.
C-C chemokine receptor type 7
, CC chemokine receptor 7
, chemokine (C-C motif) receptor 7 a
, chemokine (C-C motif) receptor 7
, c-C chemokine receptor type 7-like
, C-C CKR-7
, EBV-induced G-protein coupled receptor 1
, MIP-3 beta receptor
, chemokine (C-C) receptor 7
, epstein-Barr virus-induced G-protein coupled receptor 1
, EBV-induced G protein-coupled receptor 1
, Epstein-Barr virus induced G-protein coupled receptor
, Epstein-Barr virus induced gene 1
, lymphocyte-specific G protein-coupled peptide receptor
, chemokine receptor 7