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Mammalian Monoclonal DLG1 Primary Antibody for ISt, IHC - ABIN1304943
Jafari, Esmaili, Toufan, Aghamollaei: Bilingual proficiency and cognitive reserve in Persian-English bilingual older adults. in Aging clinical and experimental research 2015
Show all 22 Pubmed References
Human Monoclonal DLG1 Primary Antibody for ICC, IF - ABIN4305323
Cui, Hayashi, Sun, Belmares, Cobey, Phan, Schweizer, Salter, Wang, Tasker, Garman, Rabinowitz, Lu, Tymianski: PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Show all 6 Pubmed References
Human Polyclonal DLG1 Primary Antibody for ELISA, WB - ABIN451674
Mahoney, Sammut, Xavier, Cunningham, Go, Brim, Stappenbeck, Miner, Swat: Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter. in Proceedings of the National Academy of Sciences of the United States of America 2006
Human Polyclonal DLG1 Primary Antibody for ICC, IF - ABIN269417
Gardner, Naren, Bahouth et al.: Assembly of an SAP97-AKAP79-cAMP-dependent protein kinase scaffold at the type 1 PSD-95/DLG/ZO1 motif of the human beta(1)-adrenergic receptor generates a receptosome involved in receptor recycling ... in The Journal of biological chemistry 2007
Show all 4 Pubmed References
Rat (Rattus) Polyclonal DLG1 Primary Antibody for WB - ABIN1742275
Smalla, Sahin, Putzke, Tischmeyer, Gundelfinger, Kreutz: Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis. in Neurochemical research 2009
we found that Dlg1 was expressed at different stages of oocyte development. at the germinal vesicle stage, Dlg1 was present in the cytoplasm, prominently surrounding the germinal vesicle membrane. During maturation, Dlg1 became highly polarised by associating with the spindle and formed characteristic crescent (show SFRP5 Antibodies)-shaped accumulations under the cortex.
Adrenergic modulation of Kv1.1 (show KCNA2 Antibodies) was mediated by the signaling scaffold SAP97, which, through direct protein-protein interactions, escorts beta2 signaling to remove Kv1.1 (show KCNA2 Antibodies) from the dendrite surface. This process promoted spike timing-dependent long-term synaptic potentiation at mouse hippocampal excitatory synapses.
that Pten, through the Dlg1-binding ability of its PDZ (show INADL Antibodies)-binding domain , accumulates phosphorylated Eg5 (show KIF11 Antibodies) at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes
Kif13b (show KIF13B Antibodies) also negatively regulates Dlg1 stability in oligodendrocytes, in which Dlg1, in contrast to Schwann cells, enhances AKT (show AKT1 Antibodies) activation and promotes myelination
Dlg1 regulates p38 (show CRK Antibodies)-dependent proinflammatory cytokine production.
phenotypes of Dlg1-/- mice involving cellular disorganization and insufficient tissue elongation strongly suggest a defect in the convergent extension movements
Loss of Dlg1 confers strong predisposition to the development of pediatric B-ALL in a murine model.
data indicate that the surface expression and function of EAAT2b can be rapidly modulated through the disruption of its interaction with DLG1 by CaMKII (show CAMK2G Antibodies) activation.
Loss of Dlg-1 in the mouse lens impairs fibroblast growth factor receptor signaling.
lack of the Dlg1 gene induces a decrease in apoptotic epithelial cell death and the persistence of the common nephric duct, which result in a dysfunctional vesicoureteral junction and cause megaureter or hydronephrosis through vesicoureteral reflux
the increased expression of DLG1 may be predictive of an unfavorable prognosis in colorectal cancer.
By fluorescence resonance energy transfer (FRET), we detected the direct binding of Tax (show CNTN2 Antibodies) to DLG1 within the cell. The interaction specifically affects the cellular distribution of not only DLG1, but also Tax (show CNTN2 Antibodies). The aggregates distribute into the Golgi apparatus in spatial association with the microtubule-organizing center (MTOC).
These data support diverging presynaptic and postsynaptic roles of SAP97 N-terminal isoforms in synapse maturation and plasticity
Single nucleotide polymorphism in DLG1 gene is associated with schizophrenia.
Low expression of DLG1 is associated with Crohn's disease.
BAIAP2 (show BAIAP2 Antibodies) is a candidate gene for mediating dendritic spine density abnormalities in schizophrenia. Data suggest that altered DNA methylation (show HELLS Antibodies) in schizophrenia may be a mechanism for schizophrenia-related dendritic spine density reductions.
Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 contribute to maintaining Wnt/beta-catenin signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta phosphorylation.
Results suggest that discs large (show DLG4 Antibodies) tumour suppressor (DLG1) expression may have an important role in the progression of early dysplastic cervical lesions, giving prognostic information.
Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia was identified.
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known.
discs, large homolog 1 (Drosophila)
, synapse-associated protein 97
, disks large homolog 1
, Drosophila discs-large tumor suppressor homologue (synapse associated protein)
, embryo-dlg/synapse-associated protein 97
, presynaptic protein SAP97