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anti-Mouse (Murine) GRB10 Antibodies:
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Human Polyclonal GRB10 Primary Antibody for WB - ABIN1881389
ONeill, Rose, Pillay, Hotta, Olefsky, Gustafson: Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling. in The Journal of biological chemistry 1996
Show all 5 Pubmed References
ablation of growth factor receptor bound protein 10 (Grb10) in muscle is sufficient to affect muscle size and metabolism, supporting an important role for this protein in growth and metabolic pathways
DNA methylation at CpG island 1 (CGI1) of Grb10 in blastocysts were also significantly decreased after vitrification
This study reveals a function for the imprinted gene Grb10 in regulating hematopoietic stem cell self-renewal.
In tumors, Grb10 loss independently promotes Ras pathway hyperactivation, which promotes hyperproliferation, an early feature of tumor development.
This study identified Grb10 as a critical regulator of lipid metabolism, the programming of the browning phenotype, and thermogenesis in adipose tissues.
Negative regulation of Grb10 Interacting GIGYF2 protein on IGF-1 receptor signaling pathway caused diabetic mice cognitive impairment.
Grb10 is involved in BCR-ABL-positive leukemia in mice.
Grb10 is a key genetic component of developmental programming.
Glucose uptake was higher in Grb10(-/-) primary myotubes in the basal state and was associated with enhanced insulin signaling and an increase in GLUT4 translocation to the plasma membrane.
Grb10 expression in mouse embryo is regulated by Lmx1a transcription factor.
Results suggest consecutive passaging may affect epigenetic modifications of Grb10 in adult fibroblast cells.
Study has identified Grb10 as an important regulator of beta-cell proliferation and demonstrated that reducing the expression level of Grb10 could provide a novel means to increase beta-cell mass and reduce beta-cell apoptosis.
Grb10-ablated muscle from adult mice shows coordinate gene changes that oppose those of muscle wasting pathologies, highlighting Grb10 as a potential therapeutic target for these conditions
Data suggest that GRB10 is involved in pancreatic alpha cell survival and, as result, plays an important role in regulating basal glucagon secretion and glucose tolerance; studies include both apoptotic and anti-apoptotic signaling of GRB10.
mTORC1-mediated phosphorylation stabilized Grb10, leading to feedback inhibition of the phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated, mitogen-activated protein kinase (ERK-MAPK) pathways
analysis of the interaction between the growth factor-binding protein GRB10 and the E3 ubiquitin ligase NEDD4
Grb10 is, so far, a unique imprinted gene, able to influence distinct physiological processes, fetal growth and adult behaviour, owing to actions of the two parental alleles in different tissues
Grb10 gene is expressed from the paternal allele in brain, but from the maternal allele in most other tissues.
These results suggest a role for the Grb10/Nedd4 complex in regulating ubiquitination and stability of the IGF-IR, and they suggest that Grb10 serves as an adapter to form a bridge between Nedd4 and the IGF-IR.
Grb10 is a critical component of the insulin receptor (IR) signaling complex that provides a functional link between IR and p85 phosphatidylinositol (PI) 3-kinase and regulates PI 3-kinase activity.
Through syngeneic comparison, our study identifies for the first time that Grb10 is associated with the pluripotency state in nuclear transfer embryonic stem cells.
Study found FGFR3 gene mutation plus GRB10 gene duplication in a patient with achondroplasia plus growth delay with prenatal onset
Data suggest that GRB10 and GRB14 are both Ca2+-dependent CaM-binding proteins; more than one CaM-binding site and/or accessory CaM-binding sites appear to exist in GRB10 and GRB14, as compared to a single one present in GRB7. (GRB10 = growth factor receptor-bound protein 10; GRB14 = growth factor receptor-bound protein 14; CaM = calmodulin; GRB7 = growth factor receptor-bound protein 7)
GRB10 may regulate degradation of the IL-4 receptor-signaling complex through interactions with NEDD4.2.
placental expression associated positively with placental weight, birth weight, and neonatal head circumference
Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2
This study demonstrated that the most significant SNP (rs11770199; p = 0.0003) in single-site analysis was located on chromosome 7 in the GRB10 gene.
Association of the intronic polymorphism rs12540874 A>G of the GRB10 gene with high birth weight.
Tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism.
Grb10 binds to both normal and oncogenic FLT3 and induces PI3K-Akt and STAT5 signaling pathways resulting in an enhanced proliferation, survival and colony formation of hematopoietic cells.
Studies indicate that insulin receptor (IR) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10/14 and SH2B1/B2 adaptors.
H19 and GRB10 methylation was normal in Albright's hereditary osteodystrophy patients.
discovery of Grb10 as an mTORC1 substrate
Grb10 interacts with Bim L and inhibits its proapoptotic activity in a phosphorylation-dependant manner.
GRB10 gene is expressed from the paternal allele in the brain, but from the maternal allele in the placental trophoblasts.
role in inhibiting insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor
The structure of this protein's SH domains affect ligand specificity.
Grb10 acts as a positive regulator in VEGF-R2 signaling and protects VEGF-R2 from degradation by interacting with Nedd4, a component of the endocytic machinery
GRB10 protein products are correlated with parameters of birth size.
there is a phosphorylation-regulated complex formation of Grb10 with 14-3-3 and Akt
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified.
growth factor receptor-bound protein 10
, zgc:91987growth factor receptor-bound protein 10
, growth factor receptor-bound protein 10-like
, GRB10 adapter protein
, maternally expressed gene 1 protein
, GRB10 adaptor protein
, insulin receptor-binding protein Grb-IR
, maternally expressed gene 1
, adapter protein
, binds to insulin receptor and IGF1R