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Human Polyclonal OSTBETA Primary Antibody for IF (p), IHC (p) - ABIN1386750
Stipanuk, Jurkowska, Niewiadomski, Mazor, Roman, Hirschberger: Identification of Taurine-Responsive Genes in Murine Liver Using the Cdo1-Null Mouse Model. in Advances in experimental medicine and biology 2017
Dileucine motif in the extracellular N-terminal region is essential for OSTB plasma membrane targeting.
Hepatic OSTalpha (show OSTALPHA Antibodies)-OSTbeta expression is induced by hypoxia.
OSTbeta is a target of RARalpha (show RARA Antibodies)-mediated (by binding to DR5 (show TNFRSF10B Antibodies) response element) gene regulation pathways
Ostbeta is required for both proper trafficking of Ostalpha (show OSTALPHA Antibodies) and formation of the functional transport unit, and identify specific residues of Ostbeta critical for these processes.
The present report summarizes the evidence for a pleiotropic role of Ostalpha (show OSTALPHA Antibodies)-Ostbeta in different tissues.
OSTbeta is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS (show SULT2A1 Antibodies) homeostasis
OSTbeta has roles in biological transport and is widely expressed in human tissues
overexpr (show OSTALPHA Antibodies)ession of human OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate (show NR1H4 Antibodies) and the activation of FXR target genes
OSTalpha (show OSTALPHA Antibodies)/OSTbeta expression is induced by bile acids through ligand-dependent transactivation of both OST (show DDOST Antibodies) genes by the nuclear bile acid receptor (show NR1H4 Antibodies)/farnesoid X receptor (show xpr1 Antibodies) (FXR (show NR1H4 Antibodies)).
the selective localization of OSTalpha (show OSTALPHA Antibodies) and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.
Data suggest that transport of bile acid taurocholate is retained when OstB is truncated to contain only the transmembrane domain with 15 additional residues on each side and co-expressed with intact OstA (organic solute transporter alpha subunit (show OSTALPHA Antibodies)); shorter fragments of OstB are inactive.
Co-expression of mouse Ostalpha (show OSTALPHA Antibodies)-Ostbeta, but not the individual subunits, stimulated Na(+)-independent bile acid uptake and the apical-to-basolateral transport of taurocholate
OSTalpha (show OSTALPHA Antibodies) and OSTbeta mRNA levels were induced in the adrenals and kidneys of wild-type, but not FXR (show NR1H4 Antibodies)-/-, mice
In conclusion, we identified Ost-alpha (show OSTALPHA Antibodies)/Ost-beta as a novel FXR (show NR1H4 Antibodies) target. Absent Ost-alpha (show OSTALPHA Antibodies)/Ost-beta induction in CA-fed FXR (show NR1H4 Antibodies)(-/-) animals may contribute to increased liver injury in these animals.
The mouse Ostalpha (show OSTALPHA Antibodies) and Ostbeta promoters are unusual in that they contain functional FXR (show NR1H4 Antibodies) and LRH elements, which mediate, respectively, positive and negative feedback regulation by bile acids.
These results indicate that expression of Ostalpha (show OSTALPHA Antibodies) and Ostbeta are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor (show NR1H4 Antibodies).
LXRalpha (show NR1H3 Antibodies) transcriptionally regulate mouse organic solute transporter alpha (show OSTALPHA Antibodies)/beta via inverted repeat-1 elements shared with farnesoid X receptor (show xpr1 Antibodies)
Present as heterodimers (with Ost alpha (show OSTALPHA Antibodies)) and/or heteromultimers; the interaction between Ostalpha (show OSTALPHA Antibodies) and Ostbeta increases the stability of the proteins and is required for delivery of the heteromeric complex to the plasma membrane.
These data indicate that Ostalpha (show OSTALPHA Antibodies)-Ostbeta is essential for intestinal bile acid transport in mice.
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids (By similarity).
organic solute transporter beta
, organic solute transporter subunit beta
, solute carrier family 51 subunit beta
, organic solute transporter beta subunit
, Ost beta