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anti-Human ApoE3 Antibodies:
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Dementia risk was significantly higher among participants at high or intermediate APOE risk compared with those at low APOE risk ..APOE genotype significantly modified the association between protective factors and dementia
Findings suggest a meaningful relationship between APOE genotype and psychiatric distress post-military-related traumatic brain injury
Our data show that APOE4 may be associated with lower bone formation as well as increased risk of osteoporosis and bone fractures, whereas APOE3 seems to decrease lowering BMD in postmenopausal women, and its presence seemed to lower the incidence of bone breaking in patients with osteoporosis.
Results provide independent validation that the APOE CGI holds lower DNA methylation levels in AD compared to control in frontal lobe but not cerebellar tissue. Data also indicate that the non-neuronal cells of the AD brain, which are mainly composed of glia, are the main contributors to the lower APOE DNA methylation observed in AD PMB.
Participants with ApoE4(e3/e4) allele had higher levels of LDL-C (p=0.010), independently of HbA1c. CONCLUSIONS: Females and subjects with suboptimal metabolic control had more adverse lipid profiles. ApoE4(e3/e4) alleles were associated with significantly higher LDL-C levels, independently of HbA1c
Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results.
Prior work has shown that beta-amyloid and Apolipoprotein E epsilon4 combine to influence memory decline in nondemented older adults. This study indicate that increasing age may further exacerbate these effects.
APOE rs7412 and rs429358 SNPs showed a statistically significant association for the risk of cervical spondylotic myelopathy in Indian population.
ApoE4 is the largest risk factor for Alzheimer disease (AD), and is an independent risk factor for coronary heart disease (CHD); ApoE4 is likely to be the bridge between AD and CHD
APOE-e4 allele is associated with Alzheimer disease risk in Jordanian population.
Apolipoprotein E region molecular signatures of Alzheimer's disease
ApoE4 is a risk factor for TDP-43 deposition in Alzheimer's disease.
age, sex and APOE genotype robustly identify high-risk groups for Alzheimer disease and all dementia; these groups can potentially be targeted for preventive interventions
These results highlight the importance of the LSR polymorphism and reveal the existence of complex molecular links between LSR and ApoE for the regulation of lipid levels, revealing potential new pathways of interest in type III hyperlipidemia and its involvement in cardiovascular disease pathology.
These findings evidenced a novel role of BDNF in the modulation of ApoE and cholesterol homeostasis in glial and neuronal cells.
Studied the association between chronic low-grade inflammation (C reactive protein levels) and risk of Alzheimer Disease (AD) in ApoE4 carrier genotypes.
data indicate that apoE and FH interact with monocytic cells in a concerted action and this interaction reduces complement activation and inflammation in the atherosclerotic lesions.
Apolipoprotein epsilon4 prevalence and Abeta burden did not differ by sex. Sex did not directly influence cognitive decline. Females with higher Abeta exhibited faster decline than males. Post hoc contrasts suggested that females who were Abeta and apolipoprotein epsilon4 positive declined faster than their male counterparts. Findings suggest that sex may play a modifying role on risk of Alzheimer's disease-related cog...
Tests for the detection of apoE4 for patients' stratification.
Across the Alzheimer's disease/dementia with Lewy bodies spectrum: (1) hippocampal volumes were smaller with increasing APOE-epsilon4 dosage (no genotype x diagnosis interaction observed), (2) learning performance as assessed by total recall scores was associated with hippocampal volumes only among APOE-epsilon4 carriers, and (3) APOE-epsilon4 carriers performed worse on long-delay free word recall.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3