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Human Monoclonal CFL1 Primary Antibody for IF, IHC (p) - ABIN514354
Nishimura, Tsuda, Kataoka, Arao, Nomura, Chiyoda, Susumu, Nishio, Aoki: Overexpression of cofilin 1 can predict progression-free survival in patients with epithelial ovarian cancer receiving standard therapy. in Human pathology 2011
Show all 4 Pubmed References
Human Polyclonal CFL1 Primary Antibody for IF, IHC - ABIN362130
Kobayashi, Nishita, Mishima, Ohashi, Mizuno: MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration. in The EMBO journal 2006
Show all 7 Pubmed References
Human Polyclonal CFL1 Primary Antibody for IHC - ABIN965911
Wang, Shibasaki, Mizuno: Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. in The Journal of biological chemistry 2005
Show all 2 Pubmed References
Dog (Canine) Polyclonal CFL1 Primary Antibody for ICC, IF - ABIN151397
Sparrow, Manetti, Bott, Fabianac, Petrilli, Bates, Bunge, Lambert, Fernandez-Valle: The actin-severing protein cofilin is downstream of neuregulin signaling and is essential for Schwann cell myelination. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Show all 2 Pubmed References
Human Polyclonal CFL1 Primary Antibody for IHC, WB - ABIN363152
Smith-Beckerman, Fung, Williams, Auersperg, Godwin, Burlingame: Proteome changes in ovarian epithelial cells derived from women with BRCA1 mutations and family histories of cancer. in Molecular & cellular proteomics : MCP 2005
Show all 4 Pubmed References
Human Polyclonal CFL1 Primary Antibody for IF (p), IHC (p) - ABIN718646
Zhou, Wang, Fei, Zhang: Expression of cofilin 1 is positively correlated with the differentiation of human epithelial ovarian cancer. in Oncology letters 2012
Human Polyclonal CFL1 Primary Antibody for IHC, IHC (p) - ABIN4299505
Zhu, Riau, Beuerman: Epithelial microfilament regulators show regional distribution in mouse conjunctiva. in Molecular vision 2010
Results suggest that elevation of actin dynamics by Xenopus ADF/cofilin (XAC) activation through Slingshot phosphatase (XSSH) phosphorylation is required for meiotic spindle assembly.
Gastrulation movement requires ADF/cofilin activity through dynamic regulation of its phosphorylation state.
proper actin turnover mediated by Cfl1 is essential for adhesion between the deep cell layer and the enveloping layer and cell movements during gastrulation in zebrafish
Silencing of cofilin-1 led to an Accumulation of F-actin fibers and significantly decreased podocyte migration. ability
Taken together, our data suggest that Tsr is required for cell survival and tissue growth by regulating JNK (show MAPK8 Antibodies) and Yki (show YAP1 Antibodies) signaling while maintaining the epithelial integrity by controlling cell junctions. This study provides an insight into potential roles of ADF/cofilin in invasive cell migration and tumor suppression in higher animals.
Mical and cofilin, therefore, form a redox-dependent synergistic pair that promotes F-actin instability by rapidly dismantling F-actin and generating post-translationally modified actin that has altered assembly properties
Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism.
AIP1 enhances cofilin-mediated actin disassembly in the apical region of precluster cells to promote remodeling of adherense junctions.
Data show that cofilin is required for F-actin turnover and lamellipodial protrusion in the border cells.
tsr is required for planar cell polarity patterning.
These results indicate that changes in the extent of cofilin phosphorylation are regulated by Ssh in response to changes in the levels and/or organisation of F-actin.
Results show that twinstar (tsr), which encodes Drosophila cofilin/ADF (actin-depolymerizing factor), is required for elongation of the retinal cell body and the morphogenesis of the rhabdomere.
High CFL1 (show VPS72 Antibodies) expression is associated with malignant pancreatic lesions.
High CFL1 (show VPS72 Antibodies) expression is associated with epithelial-mesenchymal transition of gastric cancer.
Cofilin-1 plays a dominant role in angiotensin-(1-7)-induced G0/G1 arrest and autophagy to maintain cellular homeostasis in human aortic endothelial cells
NKCC1 (show SLC12A2 Antibodies) not only controls cell volume and Cl- concentration, but it can also regulate the actin cytoskeleton through Cofilin 1.
The enhancement of cancer cells invasion is dependent on CFL1 (show VPS72 Antibodies), a known regulator of invadopodia maturation.
The present study demonstrates that miR (show MLXIP Antibodies)-145 plays an important role in inhibiting cell migration by directly targeting PAK4 (show PAK4 Antibodies), and identifies miR (show MLXIP Antibodies)-145-PAK4 (show PAK4 Antibodies)-LIMK1 (show LIMK1 Antibodies)-cofilin as a novel regulatory pathway that contributed to colorectal cancer metastasis.
D44 and RHOA (show RHOA Antibodies) are required for CFL1 (show VPS72 Antibodies) phosphorylation and cell migration induced by CD74 (show CD74 Antibodies) in breast cancer cells.
Our results revealed that CKS1 (show CKS1B Antibodies) is involved in normal glutamatergic synapse development and dendritic spine maturation in adult hippocampus through modulating p27 (show PAK2 Antibodies) stability.
Our study indicates that Cofilin 1 holds an important position in the development and progression of human bladder cancer
Results suggest that the immune-complex (IC) of cofilin-1 in sera is a potentially attractive serum biomarker for the prognosis of pancreatic ductal adenocarcinoma (PDAC).
Myosin phosphatase and cofilin mediate cAMP/cAMP-dependent protein kinase-induced decline in endothelial cell isometric tension and myosin II regulatory light chain phosphorylation
Cyclic compression for 10 min up-regulated gene expression for the actin depolymerising proteins, cofilin and destrin (show DSTN Antibodies).
These findings suggest a causal relationship between increased Rac1 (show RAC1 Antibodies)-cofilin signaling, synaptic defects, and impaired sensory processing in fragile X (show FMR1 Antibodies) syndrome (FXS) and uncover a previously unappreciated role for impaired Rac1 (show RAC1 Antibodies)-cofilin signaling in the aberrant spine morphology and spine density associated with FXS.
Our work unraveled a novel function for cofilin1-dependent actin dynamics in mitochondrial fission, and identified cofilin1 as a negative regulator of mitochondrial DRP1 (show CRMP1 Antibodies) activity
These findings suggest that the patterning of podosomes into a sealing zone involves the dynamic interaction between cofilin, CTTN (show CTTN Antibodies), and the microtubule + ends.
the Rap1-cofilin-1 pathway coordinates actin and microtubule organization at the immune synapse.
VEGFA (show VEGFA Antibodies) induced phosphorylation of Pak1 (show PAK1 Antibodies) and its effector cofilin in a manner that was dependent on time as well as p38MAPKbeta.
Data show that the primary effect of costimulation blockade was to decrease recruitment of the activator of actin nucleation WAVE2 (Wiskott-Aldrich syndrome protein family member protein 2) and cofilin (actin-severing protein) to F-actin.
These results strongly support the active role of cofilin in ischemia-induced neuronal degeneration and apoptosis.
Caspase-11 (show CASP4 Antibodies) targets cofilin via the RhoA GTPase, whereas caspase-1 (show CASP1 Antibodies) engages the Slingshot phosphatase
aberrant cofilin phosphorylation that induces actin polymerization might be a consequence of actin disassembly induced by the absence of Rac1 (show RAC1 Antibodies).
novel roles for actin-depolymerizing factor (show DSTN Antibodies) and cofilin-1 in regulating the remodeling and permeability of epithelial junctions
In vitro, formation of cofilin oligomers was drastically reduced after phosphorylation by LIMK2 (show LIMK2 Antibodies).
glucose increases p-cofilin by phosphorylating LIMK1 through activation of Rho/Rho kinase, probably due to diacylglycerol-sensitive PKC activation resulting from increased glucose influx
Cofilin is necessary for maintaining the osmotic responsiveness of the cytoskeleton in tubular cells, and the Rho/ROCK/LIMK-mediated cofilin phosphorylation is a key mechanism in the hyperosmotic stress-induced F-actin increase.
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.
, non-muscle cofilin 1
, cofilin 1 (non-muscle)
, Cofilin/actin depolymerizing factor-like
, actin-depolymerizing factor
, no terminal filament
, twin star
, 18 kDa phosphoprotein
, cofilin, non-muscle isoform