Browse our anti-CXCL12 (CXCL12) Antibodies

Human Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. CXCL12 regulation plays a significant role in both tumor progression.

2. Conclusion Both dominant and additive models in both KCNJ11 (E23K, rs5219) and SDF-1b (G801A, rs1801157) genetic polymorphisms are significantly associated with type 2 diabetes

3. the present study indicated that CXCL12 rs1801177 and CXCR4 rs2228014 are not associated with triple negative breast cancer development in isolation, but might increase triple negative breast cancer susceptibility in combination. Also, CXCL12 polymorphism was negatively correlated with Ki67 staining.

4. Expression of CXCL12gamma induces the expression of a cancer stem cell and neuroendocrine phenotypes, resulting in the development of aggressive metastatic castration-resistant prostate cancer

5. High CXCL12 expression is associated with epithelial-mesenchymal transition in ovarian cancer.

6. Study suggests that SDF-1 G>A and CXCR4 C>T polymorphism plays a role in the development of oral squamous cell carcinoma (OSCC) and oral and pharyngeal squamous cell carcinoma (OPSCC). However, the combination of SDF-1 G>A and CXCR4 C>T did not correlate with OPSCC risk, except for OSCC.

7. Upregulation of SDF1 is associated with Angiogenesis in Degenerated Discs.

8. Gene polymorphism of CXCL12 rs2297630 is associated with the genetic risk of CAD and the severity of coronary stenosis

9. the data indicated that miR31 promoted chondrocyte viability and migration by directly targeting CXCL12, which provided evidence for CXCL12 as a potential target in osteoarthritis therapy.

10. The results suggested that cartilage endplate stem cells might promote nucleus pulposus cells proliferation in a paracrine pathway, which was partially mediated by SDF-1/CXCR4 axis via ERK1/ERK2 signaling transduction pathway.

11. SDF-1 can induce metastatic squamous cell carcinoma of the head and neck (SCCHN) by integrin alphanubeta3-CXC chemokine receptor (CXCR) 4/CXCR7 axi. LM609, AMD3100, and CCX754 and can reduce the regulation of SDF-1 on SCCHN activity.

12. our study confirmed that CXCL12 can enhance the angiogenesis potential of PDLSCs, which are crucial in the repair and regeneration of bone tissue.

13. CXCL12 rs1746048 is significantly associated with intracranial aneurysm risk in Han Chinese females, aged 65 and older.

14. These results suggest that CXCL12 regulates differentiation of melanocyte stem cells (McSCs) as well as their proper localization, and maintaining McSCs by regulating CXCL12 expression level in the bulge region may be a key to preventing hair graying.

15. Olaptesed pegol, an anti-CXCL12/SDF-1 Spiegelmer, alone and with bortezomib-dexamethasone in relapsed/refractory multiple myeloma: a Phase IIa Study.

16. In vitro human parvovirus B19-infected circulating angiogenic cells showed up-regulation of surface CXCR4 with increased migratory capacity further enhanced by elevated SDF-1alpha concentrations. Overexpression of the human parvovirus B19 capsid protein VP2 was associated with this effect.

17. this study indicated that CXCL12, CXCR4, and CXCR7 were differentially expressed and regulated in u-THP-1 and d-THP-1 cells in response to external stimuli. Importantly, we reported here a novel observation that uncoupling exists between transcriptional and translational regulation of CXCR4, 7 expressions by differentiation and TLR stimuli.

18. CXCL12-stimulated CXCR7 acts as a functional receptor to activate Akt for angiogenesis in HUVECs and that CXCR7 may be a potential target molecule for endothelial regeneration and repair after vascular injury.

19. the present data demonstrated that CXCL12 served an important role in the radioresistance of cervical cancer, suggestinh a novel therapeutic target.

20. CXCL12-positive cases exhibited shorter disease-free survival rates compared to CXCL12-negative cases.

Rhesus Monkey Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. these results demonstrate that a cross-talk exists between the TGF-beta1 and SDF-1 pathways in choroid-retinal endothelial cells

2. following optic nerve crush, the levels of endogenous SDF-1alpha and CXCR4 increase in the retina and optic nerve, where activated glial cells may act as a source of increased SDF-1alpha protein.

3. The CXCR7/CXCR4/CXCL12 axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.

Mouse (Murine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. a new mechanism where CXCL12-signals from granule neurons prevent dispersion and support maturation of newborn granule neurons

2. concluded that SDF-1/CXCR4 pathway improved diabetic retinopathy possibly by increasing cell viability

3. findings suggest that CXCL12/CXCR4 signaling contributes to hypernociception after chronic compression of dorsal root ganglia

4. Migration of iPSCs activated by CXCL12 is associated with significant phosphorylation of AKT

5. Study indicated that the up-regulated expression of CXCL12 in IFN-gamma induced abortion mouse uteri was not directly the responding of the administration of IFN-gamma. The up-regulated expression of CXCL12 in the later stage of aborted mouse uteri played an anti-inflammatory role that involves in the process of endometrial restoration after abortion.

6. AnnexinA7 positively regulates expression levels of SDF1/CXCR4

7. tested for possible epistasis between Tbx1 and the CXCL12 signalling axis by examining Tbx1 and Cxcl12 double heterozygotes as well as Tbx1/Cxcl12/Cxcr4 triple heterozygotes, but failed to identify any exacerbation of the Tbx1 haploinsufficient arch artery phenotype

8. SDF-1/CXCR4 pathway may play an important role in fracture healing following bone mesenchymal stem cell transplantation.

9. Cross-talk between fibroblast-derived CXCL12 and endothelial cells could be used as novel biomarker.

10. these findings identify the CXCR4-CXCL12 axis as a potential therapeutic target likely due to its importance for antibody-secreting cell homing and survival

11. miR-342 is involved in MS-K tumor growth as a tumor suppressor by targeting chemokine CXCL12.

12. superparamagnetic iron oxide nanoparticles also stimulated CXCR4 (C-X-C chemokine receptor type 4) expression and CXCR4-SDF-1 (Stromal cell-derived factor 1) signaling in mesenchymal stem cells.

13. This study regarding high SDF-1 levels in our mouse model of ototoxicity would play a major role in the development of therapeutic agents using MSC homing.

14. CXCL12-CXCR4 signalling is essential for the correct patterning of aortic arches and pulmonary arteries during development.

15. Data (including data from studies in knockout mice) suggest that adipocyte autocrine function involving Sdf1 regulates insulin resistance; Sdf1 gene expression correlates with insulin-desensitized conditions in adipocytes but not other tissues (liver, skeletal muscle); adipocyte-specific ablation of Sdf1 enhances insulin sensitivity in adipose tissues and in whole body.

16. postnatal CXCL12 signaling promotes a specific interneuron circuit that inhibits medial prefrontal cortex activity

17. Study reports that stromal cell-derived factor-1alpha elevated or therapeutically administered in ischemic wounded tissue can stimulate both local endothelial cells (EC) and bone marrow-derived endothelial progenitor cells (EPC) to express reciprocally E-selectin/ligand pairs and thereby enhance EPC-EC interactions.

18. suggest that miR-155 modulates SHIP-1 expression that subsequently affects CXCL12-CXCR4 signaling axis via Akt activation

19. Authors produced recombinant CXCL12 and CXCL12(5-67) and evaluated their effect in murine adult NSCs migration and survival in vitro. We showed CXCL12(5-67) does not promote NSCs migration, but does induce cell death.

20. Study demonstrates that CXCR4/CXCL12 axis can limit oxidative stress injury in hematopoietic stem cells (HSCs) by reducing mitochondrial oxidative stress. CXCL12 has a direct rescue effect on oxidative stress-induced HSC damage at the mitochondrial level.

Xenopus laevis Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. These findings support the conservation of sdf-1alpha signaling in vertebrate somite morphogenesis; however, the precise mechanism by which this signaling pathway influences somite morphogenesis is different between the fish and the frog.

2. expression patterns of xSDF-1a, xCXCR4, and xCXCR7 during gastrulation; results suggest SDF-1 signaling supports migration of the mesendoderm cell cohort toward the animal pole and that activin/nodal signaling acts as a regulator of the expression of xSDF-1a and xCXCR4, but not xCXCR7

3. SDF-1/CXCR4 chemokine signaling is involved in the migration and survival or in the differentiation of PGCs in Xenopus

4. A significant increase of stromal cell-derived factor-1alpha and CXCR4 was observed in protein extracts of idiopathic inflammatory myopathies in comparison with normal controls.

5. SDF-1 signaling is necessary for migrations of massive numbers of cells during gastrulation.

Pig (Porcine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. Polymorphisms in CXCL12 are significantly associated with immunological traits in Landrace piglets and have potential application value for marker-assisted selection of pig breeding with disease resistance.

2. The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1/CXCR4 axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.

Cow (Bovine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. Findings indicate that stromal fibroblasts within mammary glands with mastitis contribute to EMT and inflammatory responses of epithelial cells through the secretion of SDF-1, which could result in the inflammation spread and fibrosis within mammary gland.

2. There is a potential link between follicular SDF1/CXCR4 activation and the regulation of ovulation-related genes in cows and horses.

3. Polymorphism of intron 2 of the SDF1 gene in Galloway, Hereford, and Russian Black Pied cattle

Zebrafish Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. formulate a mathematical model of a laser ablated primordium separated into two smaller cell collectives: a leading collective that responds to local CXCL12a levels and a trailing collective that migrates up a local FGF gradient.

2. Cxcl12 and Myc facilitate glycolysis to promote fast migratory responses during development and repair during kidney injury and development

3. snail1b expression is initiated by chemokines first encountered by leading primordium cells and its expression plays a crucial role in initiating collective migration of the posterior lateral line primordium.

4. Study demonstrates that forced expression of Sdf1a in the fish embryo during early development is an effective strategy to disrupt primordial germ cell migration and produce large populations of infertile fish.

5. miR-126a directs lymphatic endothelial cell sprouting and extension by interacting with Cxcl12a-mediated chemokine signaling and Vegfc-Flt4 signal axis.

6. filopodia distribution and their dynamics are dictated by the gradient of the chemokine Cxcl12a.

7. Our data show that elevated concentrations of circulating CXCL12a in pulmonary hypertension predicted poorer survival

8. SDF1a directly controls the migration of both leading and trailing edges of a tissue through the activation of two independent receptors, CXCR4b and CXCR7.

9. Prospective isolation and culture of sdf1(DsRed) perivascular cells demonstrated properties consistent with mesenchymal stem cells.

10. Study shows that the primordium generates an attractant gradient across itself by sequestering Sdf1a protein in its rear via Cxcr7-mediated chemokine uptake. This self-generated attractant gradient, combined with the route information provided by the stripe of sdf1a-expressing cells, then provides directional guidance to the migrating primordium.

11. gata4 gene regulates sdf1a levels during early embryogenesis

12. These findings suggest an "attractive path" model in which migrating cells closely follow a dynamic SDF1a source that is refined on a transcript and protein level by miR-430 and Cxcr7b, respectively.

13. sdf-1 expression and function in the adult zebrafish have important similarities to mammals

14. Expression of Cxcl12 and Cxclr4 in radial glial cells of the adult zebrafish brain supports important roles for the Cxcl12/Cxcr4 pair in brain development and functioning.

15. A single amino acid exchange switches the relative affinity of the Cxcl12 ligands for one of the duplicated Cxcr4 receptors, thereby determining the functional specialization of each chemokine that elicits a distinct function in a distinct process.

16. we demonstrate that miR-430-mediated regulation of endogenous sdf1a and cxcr7b facilitates dynamic expression of sdf1a by clearing its mRNA from previous expression domains.

17. Study suggest that the Cxcl12a-Cxcr4b ligand-receptor pair are involved in the migration of GnRH3 neurons in zebrafish, and are therefore crucial for the development of this system.

18. A trail of SDF1-like chemokine encoded by the sdf1a gene is present along the pathway of the lateral line primordium. Both the formation and the innervation of this system depend on the SDF1-CXCR4 system

19. SDF1/CXCR4-mediated cell migration is preferentially associated with movement along the anteroposterior axis of the animal

20. SDF-1/CXCR4 signaling is important for guiding retinal ganglion cell axons within the retina to the optic stalk to exit the retina.