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anti-Human CXCL12 Antibodies:
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Human Monoclonal CXCL12 Primary Antibody for CyTOF, ELISA (Capture) - ABIN4899704
Villalba, Salvucci, Aoki, De La Luz Sierra, Gupta, Davis, Wyvill, Little, Yarchoan, Tosato: Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo. in Journal of leukocyte biology 2003
Show all 39 Pubmed References
Human Monoclonal CXCL12 Primary Antibody for FACS - ABIN4896548
Hoellenriegel, Zboralski, Maasch, Rosin, Wierda, Keating, Kruschinski, Burger: The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization. in Blood 2014
Show all 5 Pubmed References
Human Polyclonal CXCL12 Primary Antibody for IF (p), IHC (p) - ABIN1386329
Pei, Zeng, Han, Liao, Zhou, Li, Zhang, Liu, Zhang, Liu, Yao, Xu: Renal interstitial infiltration and tertiary lymphoid organ neogenesis in IgA nephropathy. in Clinical journal of the American Society of Nephrology : CJASN 2014
Show all 3 Pubmed References
Human Polyclonal CXCL12 Primary Antibody for ELISA, Func - ABIN4301060
Nistala, Habibi, Aroor, Sowers, Hayden, Meuth, Knight, Hancock, Klein, DeMarco, Whaley-Connell: DPP4 inhibition attenuates filtration barrier injury and oxidant stress in the zucker obese rat. in Obesity (Silver Spring, Md.) 2014
Show all 2 Pubmed References
Human Monoclonal CXCL12 Primary Antibody for FACS - ABIN4896551
Patenaude, Perreault: Thymic Mesenchymal Cells Have a Distinct Transcriptomic Profile. in Journal of immunology (Baltimore, Md. : 1950) 2016
Human Polyclonal CXCL12 Primary Antibody for EIA, Func - ABIN116229
Schlaepfer, Audigé, Joller, Speck: TLR7/8 triggering exerts opposing effects in acute versus latent HIV infection. in Journal of immunology (Baltimore, Md. : 1950) 2006
Human Polyclonal CXCL12 Primary Antibody for ELISA, WB - ABIN2476434
Prociv, Walker, Whitby: Human ectopic fascioliasis in Australia: first case reports. in The Medical journal of Australia 1992
Show all 3 Pubmed References
Human Polyclonal CXCL12 Primary Antibody for Func, IHC (p) - ABIN2476433
Nagasawa, Tachibana, Kishimoto: A novel CXC chemokine PBSF/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infection. in Seminars in immunology 1998
Show all 3 Pubmed References
Cow (Bovine) Polyclonal CXCL12 Primary Antibody for WB - ABIN2774605
Sadir, Imberty, Baleux, Lortat-Jacob: Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV. in The Journal of biological chemistry 2004
Show all 2 Pubmed References
These results suggest a key role for the CXCR4 (show CXCR4 Antibodies)-CXCL12 chemokine axis in breast cancer progression and highlight the prognostic importance of this chemokine (show CCL1 Antibodies) axis for breast cancer survival.
serum SDF-1 is increased in and may be a potential useful marker for primary biliary cholangitis
disruption of the CXCR4 (show CXCR4 Antibodies)/CXCL12 axis by CXCR4 (show CXCR4 Antibodies) antagonist AMD3100 blocked the contribution of both cancer and stromal cells to the metastatic cascade in the liver.
SDF-1 alpha overexpression in bone marrow-derived stromal stem cells promotes bone generation as indicated by osteogenesis and angiogenesis.
Rac1 plays a role in CXCL12 but not CCL3 (show CCL3 Antibodies)-induced chemotaxis.
These results suggest that SDF1, as an inflammatory cytokine, induces MMP expression in human endplate chondrocytes and that ECM (show MMRN1 Antibodies) remodeling in the degenerated cartilage endplate may be a favorable factor of endogenous stem cell homing into the nucleus pulposus for regeneration in vivo
data demonstrate that: (i) hypoxia does not affect the capacity of EPCs to support the angiogenic process; (ii) the absence of either VEGF-A (show VEGFA Antibodies) or SDF-1 from EPC (show TCF21 Antibodies)-CM can be rescued by the presence of the other one, so that the overall angiogenic effects remain unchanged; and (iii) and the concomitant deletion of VEGF-A (show VEGFA Antibodies) and SDF-1 from EPC (show TCF21 Antibodies)-CM impairs its pro-angiogenic effect, both in vitro and in vivo.
Data support the importance of SDF-1 and CXCR4 (show CXCR4 Antibodies) expression for loco-regional control and overall survival in HNSCC after primary radiochemotherapy.
Data (including data from studies in knockout mice) suggest that adipocyte autocrine function involving SDF1 regulates insulin (show INS Antibodies) resistance; SDF1 gene expression correlates with insulin (show INS Antibodies)-desensitized conditions in adipocytes but not other tissues (liver, skeletal muscle); adipocyte-specific ablation of Sdf1 enhances insulin (show INS Antibodies) sensitivity in adipose tissues and in whole body.
Study reports that stromal cell-derived factor-1alpha elevated or therapeutically administered in ischemic wounded tissue can stimulate both local endothelial cells (EC) and bone marrow-derived endothelial progenitor cells (EPC (show TCF21 Antibodies)) to express reciprocally E-selectin (show SELE Antibodies)/ligand pairs and thereby enhance EPC (show TCF21 Antibodies)-EC interactions.
these results demonstrate that a cross-talk exists between the TGF-beta1 (show TGFB1 Antibodies) and SDF-1 pathways in choroid-retinal endothelial cells
following optic nerve crush, the levels of endogenous SDF-1alpha and CXCR4 (show CXCR4 Antibodies) increase in the retina and optic nerve, where activated glial cells may act as a source of increased SDF-1alpha protein.
The CXCR7 (show CXCR7 Antibodies)/CXCR4 (show CXCR4 Antibodies)/CXCL12 axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.
This study regarding high SDF-1 levels in our mouse model of ototoxicity would play a major role in the development of therapeutic agents using MSC (show MSC Antibodies) homing.
CXCL12-CXCR4 (show CXCR4 Antibodies) signalling is essential for the correct patterning of aortic arches and pulmonary arteries during development.
Data (including data from studies in knockout mice) suggest that adipocyte autocrine function involving Sdf1 regulates insulin (show INS Antibodies) resistance; Sdf1 gene expression correlates with insulin (show INS Antibodies)-desensitized conditions in adipocytes but not other tissues (liver, skeletal muscle); adipocyte-specific ablation of Sdf1 enhances insulin (show INS Antibodies) sensitivity in adipose tissues and in whole body.
postnatal CXCL12 signaling promotes a specific interneuron circuit that inhibits medial prefrontal cortex activity
suggest that miR (show MLXIP Antibodies)-155 modulates SHIP-1 (show INPP5D Antibodies) expression that subsequently affects CXCL12-CXCR4 (show CXCR4 Antibodies) signaling axis via Akt (show AKT1 Antibodies) activation
Authors produced recombinant CXCL12 and CXCL12(5-67) and evaluated their effect in murine adult NSCs migration and survival in vitro. We showed CXCL12(5-67) does not promote NSCs migration, but does induce cell death.
Study demonstrates that CXCR4 (show CXCR4 Antibodies)/CXCL12 axis can limit oxidative stress injury in hematopoietic stem cells (HSCs) by reducing mitochondrial oxidative stress. CXCL12 has a direct rescue effect on oxidative stress-induced (show SQSTM1 Antibodies) HSC (show FUT1 Antibodies) damage at the mitochondrial level.
a defect of CXCL12 promoter histone acetylation may represent an additional process participating in CXCL12 expression extinction in colon cancer
The structure of murine germinal centers (GC) and the localization of GC B (show NPR2 Antibodies) cells are impaired when CXCL12 is unable to bind to cellular or extracellular surfaces.
expression patterns of xSDF-1a, xCXCR4, and xCXCR7 during gastrulation; results suggest SDF-1 signaling supports migration of the mesendoderm cell cohort toward the animal pole and that activin/nodal signaling acts as a regulator of the expression of xSDF-1a and xCXCR4, but not xCXCR7
SDF-1/CXCR4 chemokine (show CCL1 Antibodies) signaling is involved in the migration and survival or in the differentiation of PGCs in Xenopus
A significant increase of stromal cell-derived factor-1alpha and CXCR4 was observed in protein extracts of idiopathic inflammatory myopathies in comparison with normal controls.
SDF-1 signaling is necessary for migrations of massive numbers of cells during gastrulation.
Polymorphisms in CXCL12 are significantly associated with immunological traits in Landrace piglets and have potential application value for marker-assisted selection of pig breeding with disease resistance.
The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1/CXCR4 (show CXCR4 Antibodies) axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.
Findings indicate that stromal fibroblasts within mammary glands with mastitis contribute to EMT (show ITK Antibodies) and inflammatory responses of epithelial cells through the secretion of SDF-1, which could result in the inflammation spread and fibrosis within mammary gland.
There is a potential link between follicular SDF1/CXCR4 (show CXCR4 Antibodies) activation and the regulation of ovulation-related genes in cows and horses.
Polymorphism of intron 2 of the SDF1 gene in Galloway, Hereford, and Russian Black Pied cattle
Study demonstrates that forced expression of Sdf1a in the fish embryo during early development is an effective strategy to disrupt primordial germ cell migration and produce large populations of infertile fish.
miR (show MYLIP Antibodies)-126a directs lymphatic endothelial cell sprouting and extension by interacting with Cxcl12a-mediated chemokine (show CCL1 Antibodies) signaling and Vegfc (show VEGFC Antibodies)-Flt4 (show FLT4 Antibodies) signal axis.
filopodia distribution and their dynamics are dictated by the gradient of the chemokine (show CCL1 Antibodies) Cxcl12a.
SDF1a directly controls the migration of both leading and trailing edges of a tissue through the activation of two independent receptors, CXCR4b and CXCR7 (show CXCR7 Antibodies).
Prospective isolation and culture of sdf1(DsRed) perivascular cells demonstrated properties consistent with mesenchymal stem cells.
Study shows that the primordium generates an attractant gradient across itself by sequestering Sdf1a protein in its rear via Cxcr7 (show CXCR7 Antibodies)-mediated chemokine (show CCL1 Antibodies) uptake. This self-generated attractant gradient, combined with the route information provided by the stripe of sdf1a-expressing cells, then provides directional guidance to the migrating primordium.
gata4 (show GATA4 Antibodies) gene regulates sdf1a levels during early embryogenesis
These findings suggest an "attractive path" model in which migrating cells closely follow a dynamic SDF1a source that is refined on a transcript and protein level by miR (show MYLIP Antibodies)-430 and Cxcr7b, respectively.
sdf-1 expression and function in the adult zebrafish have important similarities to mammals
Expression of Cxcl12 and Cxclr4 in radial glial cells of the adult zebrafish brain supports important roles for the Cxcl12/Cxcr4 (show CXCR4 Antibodies) pair in brain development and functioning.
This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.
intercrine reduced in hepatomas
, pre-B cell growth-stimulating factor
, stromal cell-derived factor 1
, chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)
, chemokine CXCL12/SDF-1ALPHA
, stromal cell-derived factor 1 isoform alpha
, stromal cell-derived factor 1 isoform gamma
, 12-O-tetradecanoylphorbol 13-acetate repressed protein 1
, pre-B-cell growth-stimulating factor
, thymic lymphoma cell-stimulating factor
, SDF-1 gamma
, Stromal cell-derived factor 1
, stromal cell-derived factor-1 gamma
, C-X-C motif chemokine 12
, stromal-derived factor 1
, chemokine ligand 12b
, stromal cell derived factor 1
, stromal cell-derived factor-1 beta
, CXC chemokine
, CXCL12 chemokine
, chemokine ligand 12
, unm t30516