Browse our anti-CXCL12 (CXCL12) Antibodies

Human Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. A basis for understanding how multiple elements in the sequence encoding the 3'UTR (show UTS2R Antibodies) of the CXCL12 gene regulates its transcription and insights about diseases involving abnormal CXCL12alpha expression.

2. High SDF-1 expression is associated with bladder cancer progression.

3. High CXCL12 expression is associated with metastasis in colon cancer.

4. MiR (show MLXIP Antibodies)-125b functions as an important downstream mediator upon the activation of CXCL12/CXCR4 (show CXCR4 Antibodies) axis.

5. CXCL12-related rs18011517 polymorphism was more frequent in non-Hodgkin lymphoma patients: it might be associated with non-Hodgkin lymphoma pathogenesis and outcome

6. Data suggest that CXCL12 and its receptor CXCR4 are critical in maintaining homeostasis, specifically during hematopoiesis. Present clinical trials (especially in hematological tumors) are testing whether adding CXCR4 inhibitors to impair tumor dissemination will increase effectiveness of ongoing anti-cancer treatments. (CXCL12 = C-X-C motif chemokine ligand 12; CXCR4 = C-X-C motif chemokine receptor-4) [REVIEW]

7. BCP (show OPN1SW Antibodies)-ALL cells actively migrate toward mesenchymal stromal cells (MSCs) in a CXCL12-dependent manner.

8. Serum CXCR4 (show CXCR4 Antibodies) and CXCL12 levels increase significantly in septic neonates and they are valuable marker in diagnosis of neonatal sepsis. Serum concentrations of both chemokines represent promising novel biomarkers for neonatal sepsis.

9. CXCL12 and CXCR4 (show CXCR4 Antibodies) polymorphisms may be risk factors for hepatocellular carcinoma (HCC (show FAM126A Antibodies)), and they may be potential HCC (show FAM126A Antibodies) markers.

10. Stromal cell derived factor-1/C-X-C chemokine receptor type 4 (show CXCR4 Antibodies) axis induces human dental pulp stem cell migration through FAK (show PTK2 Antibodies)/PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) and GSK3beta/beta-catenin (show CTNNB1 Antibodies) pathways.

Rhesus Monkey Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. these results demonstrate that a cross-talk exists between the TGF-beta1 (show TGFB1 Antibodies) and SDF-1 pathways in choroid-retinal endothelial cells

2. following optic nerve crush, the levels of endogenous SDF-1alpha and CXCR4 (show CXCR4 Antibodies) increase in the retina and optic nerve, where activated glial cells may act as a source of increased SDF-1alpha protein.

3. The CXCR7 (show CXCR7 Antibodies)/CXCR4 (show CXCR4 Antibodies)/CXCL12 axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.

Mouse (Murine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. superparamagnetic iron oxide nanoparticles also stimulated CXCR4 (C-X-C chemokine receptor type 4 (show CXCR4 Antibodies)) expression and CXCR4 (show CXCR4 Antibodies)-SDF-1 (Stromal cell-derived factor 1) signaling in mesenchymal stem cells.

2. This study regarding high SDF-1 levels in our mouse model of ototoxicity would play a major role in the development of therapeutic agents using MSC (show MSC Antibodies) homing.

3. CXCL12-CXCR4 (show CXCR4 Antibodies) signalling is essential for the correct patterning of aortic arches and pulmonary arteries during development.

4. Data (including data from studies in knockout mice) suggest that adipocyte autocrine function involving Sdf1 regulates insulin (show INS Antibodies) resistance; Sdf1 gene expression correlates with insulin (show INS Antibodies)-desensitized conditions in adipocytes but not other tissues (liver, skeletal muscle); adipocyte-specific ablation of Sdf1 enhances insulin (show INS Antibodies) sensitivity in adipose tissues and in whole body.

5. postnatal CXCL12 signaling promotes a specific interneuron circuit that inhibits medial prefrontal cortex activity

6. Study reports that stromal cell-derived factor-1alpha elevated or therapeutically administered in ischemic wounded tissue can stimulate both local endothelial cells (EC) and bone marrow-derived endothelial progenitor cells (EPC (show TCF21 Antibodies)) to express reciprocally E-selectin (show SELE Antibodies)/ligand pairs and thereby enhance EPC (show TCF21 Antibodies)-EC interactions.

7. suggest that miR (show MLXIP Antibodies)-155 modulates SHIP-1 (show INPP5D Antibodies) expression that subsequently affects CXCL12-CXCR4 (show CXCR4 Antibodies) signaling axis via Akt (show AKT1 Antibodies) activation

8. Authors produced recombinant CXCL12 and CXCL12(5-67) and evaluated their effect in murine adult NSCs migration and survival in vitro. We showed CXCL12(5-67) does not promote NSCs migration, but does induce cell death.

9. Study demonstrates that CXCR4 (show CXCR4 Antibodies)/CXCL12 axis can limit oxidative stress injury in hematopoietic stem cells (HSCs) by reducing mitochondrial oxidative stress. CXCL12 has a direct rescue effect on oxidative stress-induced (show SQSTM1 Antibodies) HSC (show FUT1 Antibodies) damage at the mitochondrial level.

10. a defect of CXCL12 promoter histone acetylation may represent an additional process participating in CXCL12 expression extinction in colon cancer

Xenopus laevis Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. expression patterns of xSDF-1a, xCXCR4, and xCXCR7 during gastrulation; results suggest SDF-1 signaling supports migration of the mesendoderm cell cohort toward the animal pole and that activin/nodal signaling acts as a regulator of the expression of xSDF-1a and xCXCR4, but not xCXCR7

2. SDF-1/CXCR4 chemokine (show CCL1 Antibodies) signaling is involved in the migration and survival or in the differentiation of PGCs in Xenopus

3. A significant increase of stromal cell-derived factor-1alpha and CXCR4 was observed in protein extracts of idiopathic inflammatory myopathies in comparison with normal controls.

4. SDF-1 signaling is necessary for migrations of massive numbers of cells during gastrulation.

Pig (Porcine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. Polymorphisms in CXCL12 are significantly associated with immunological traits in Landrace piglets and have potential application value for marker-assisted selection of pig breeding with disease resistance.

2. The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1/CXCR4 (show CXCR4 Antibodies) axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.

Cow (Bovine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. Findings indicate that stromal fibroblasts within mammary glands with mastitis contribute to EMT (show ITK Antibodies) and inflammatory responses of epithelial cells through the secretion of SDF-1, which could result in the inflammation spread and fibrosis within mammary gland.

2. There is a potential link between follicular SDF1/CXCR4 (show CXCR4 Antibodies) activation and the regulation of ovulation-related genes in cows and horses.

3. Polymorphism of intron 2 of the SDF1 gene in Galloway, Hereford, and Russian Black Pied cattle

Zebrafish Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. Study demonstrates that forced expression of Sdf1a in the fish embryo during early development is an effective strategy to disrupt primordial germ cell migration and produce large populations of infertile fish.

2. miR (show MYLIP Antibodies)-126a directs lymphatic endothelial cell sprouting and extension by interacting with Cxcl12a-mediated chemokine (show CCL1 Antibodies) signaling and Vegfc (show VEGFC Antibodies)-Flt4 (show FLT4 Antibodies) signal axis.

3. filopodia distribution and their dynamics are dictated by the gradient of the chemokine (show CCL1 Antibodies) Cxcl12a.

4. SDF1a directly controls the migration of both leading and trailing edges of a tissue through the activation of two independent receptors, CXCR4b and CXCR7 (show CXCR7 Antibodies).

5. Prospective isolation and culture of sdf1(DsRed) perivascular cells demonstrated properties consistent with mesenchymal stem cells.

6. Study shows that the primordium generates an attractant gradient across itself by sequestering Sdf1a protein in its rear via Cxcr7 (show CXCR7 Antibodies)-mediated chemokine (show CCL1 Antibodies) uptake. This self-generated attractant gradient, combined with the route information provided by the stripe of sdf1a-expressing cells, then provides directional guidance to the migrating primordium.

7. gata4 (show GATA4 Antibodies) gene regulates sdf1a levels during early embryogenesis

8. These findings suggest an "attractive path" model in which migrating cells closely follow a dynamic SDF1a source that is refined on a transcript and protein level by miR (show MYLIP Antibodies)-430 and Cxcr7b, respectively.

9. sdf-1 expression and function in the adult zebrafish have important similarities to mammals

10. Expression of Cxcl12 and Cxclr4 in radial glial cells of the adult zebrafish brain supports important roles for the Cxcl12/Cxcr4 (show CXCR4 Antibodies) pair in brain development and functioning.