Browse our anti-CXCL12 (CXCL12) Antibodies

Human Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. this study indicated that CXCL12, CXCR4, and CXCR7 were differentially expressed and regulated in u-THP-1 and d-THP-1 cells in response to external stimuli. Importantly, we reported here a novel observation that uncoupling exists between transcriptional and translational regulation of CXCR4, 7 expressions by differentiation and TLR stimuli.

2. CXCL12-stimulated CXCR7 acts as a functional receptor to activate Akt for angiogenesis in HUVECs and that CXCR7 may be a potential target molecule for endothelial regeneration and repair after vascular injury.

3. the present data demonstrated that CXCL12 served an important role in the radioresistance of cervical cancer, suggestinh a novel therapeutic target.

4. CXCL12-positive cases exhibited shorter disease-free survival rates compared to CXCL12-negative cases.

5. this study shows an essential role of CXCR7, together with CXCR4, in the control of normal and malignant hematopoietic cell migration and homing induced by CXCL12.

6. CXCL12 rs1801157 is independently associated with Human papillomavirus infection and exerts influence in high grade intraepithelial lesions development

7. silencing of CXCL12 had a protective effect on podocyte injury, which may be through inhibiting CXCL12/STAT3 signaling pathway.

8. The CXCL12/SDF1 protein expression is a good prognostic biomarker in breast cancer.

9. the CXCL12-CXCR4 axis promotes the migration, invasion, and EMT processes in B-CPAP cells, at least partly, by activating the NF-kappaB signaling pathway.

10. Study shows that CXCL12 methylation-mediated epigenetic regulation of gene expression in papillary thyroid carcinoma (PTC). The study was the first to perform an reduced representation bisulfite sequencing analysis for PTC and suggested that CXCL12 may contribute to PTC development by methylation-mediated epigenetic regulation of gene expression.

11. results demonstrate that non-oxidizable HMGB1 induce a sustained cardiac fibroblasts migration despite the redox state of the environment and by altering CXCL12/CXCR4 axis. This affects proper cardiac remodeling after an infarction.

12. A basis for understanding how multiple elements in the sequence encoding the 3'UTR of the CXCL12 gene regulates its transcription and insights about diseases involving abnormal CXCL12alpha expression.

13. High SDF-1 expression is associated with bladder cancer progression.

14. High CXCL12 expression is associated with metastasis in colon cancer.

15. MiR-125b functions as an important downstream mediator upon the activation of CXCL12/CXCR4 axis.

16. CXCL12-related rs18011517 polymorphism was more frequent in non-Hodgkin lymphoma patients: it might be associated with non-Hodgkin lymphoma pathogenesis and outcome

17. Data suggest that CXCL12 and its receptor CXCR4 are critical in maintaining homeostasis, specifically during hematopoiesis. Present clinical trials (especially in hematological tumors) are testing whether adding CXCR4 inhibitors to impair tumor dissemination will increase effectiveness of ongoing anti-cancer treatments. (CXCL12 = C-X-C motif chemokine ligand 12; CXCR4 = C-X-C motif chemokine receptor-4) [REVIEW]

18. BCP-ALL cells actively migrate toward mesenchymal stromal cells (MSCs) in a CXCL12-dependent manner.

19. Serum CXCR4 and CXCL12 levels increase significantly in septic neonates and they are valuable marker in diagnosis of neonatal sepsis. Serum concentrations of both chemokines represent promising novel biomarkers for neonatal sepsis.

20. CXCL12 and CXCR4 polymorphisms may be risk factors for hepatocellular carcinoma (HCC), and they may be potential HCC markers.

Rhesus Monkey Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. these results demonstrate that a cross-talk exists between the TGF-beta1 and SDF-1 pathways in choroid-retinal endothelial cells

2. following optic nerve crush, the levels of endogenous SDF-1alpha and CXCR4 increase in the retina and optic nerve, where activated glial cells may act as a source of increased SDF-1alpha protein.

3. The CXCR7/CXCR4/CXCL12 axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.

Mouse (Murine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. SDF-1/CXCR4 pathway may play an important role in fracture healing following bone mesenchymal stem cell transplantation.

2. Cross-talk between fibroblast-derived CXCL12 and endothelial cells could be used as novel biomarker.

3. these findings identify the CXCR4-CXCL12 axis as a potential therapeutic target likely due to its importance for antibody-secreting cell homing and survival

4. miR-342 is involved in MS-K tumor growth as a tumor suppressor by targeting chemokine CXCL12.

5. superparamagnetic iron oxide nanoparticles also stimulated CXCR4 (C-X-C chemokine receptor type 4) expression and CXCR4-SDF-1 (Stromal cell-derived factor 1) signaling in mesenchymal stem cells.

6. This study regarding high SDF-1 levels in our mouse model of ototoxicity would play a major role in the development of therapeutic agents using MSC homing.

7. CXCL12-CXCR4 signalling is essential for the correct patterning of aortic arches and pulmonary arteries during development.

8. Data (including data from studies in knockout mice) suggest that adipocyte autocrine function involving Sdf1 regulates insulin resistance; Sdf1 gene expression correlates with insulin-desensitized conditions in adipocytes but not other tissues (liver, skeletal muscle); adipocyte-specific ablation of Sdf1 enhances insulin sensitivity in adipose tissues and in whole body.

9. postnatal CXCL12 signaling promotes a specific interneuron circuit that inhibits medial prefrontal cortex activity

10. Study reports that stromal cell-derived factor-1alpha elevated or therapeutically administered in ischemic wounded tissue can stimulate both local endothelial cells (EC) and bone marrow-derived endothelial progenitor cells (EPC) to express reciprocally E-selectin/ligand pairs and thereby enhance EPC-EC interactions.

11. suggest that miR-155 modulates SHIP-1 expression that subsequently affects CXCL12-CXCR4 signaling axis via Akt activation

12. Authors produced recombinant CXCL12 and CXCL12(5-67) and evaluated their effect in murine adult NSCs migration and survival in vitro. We showed CXCL12(5-67) does not promote NSCs migration, but does induce cell death.

13. Study demonstrates that CXCR4/CXCL12 axis can limit oxidative stress injury in hematopoietic stem cells (HSCs) by reducing mitochondrial oxidative stress. CXCL12 has a direct rescue effect on oxidative stress-induced HSC damage at the mitochondrial level.

14. a defect of CXCL12 promoter histone acetylation may represent an additional process participating in CXCL12 expression extinction in colon cancer

15. The structure of murine germinal centers (GC) and the localization of GC B cells are impaired when CXCL12 is unable to bind to cellular or extracellular surfaces.

16. These findings indicate that the CXCL12alpha-CXCR4 axis plays an important role in the regeneration of the neuromuscular junction after motor axon injury.

17. Here, we show that cabozantinib rapidly eradicates invasive, poorly differentiated PTEN/p53-deficient murine prostate cancer. This was associated with enhanced release of neutrophil chemotactic factors from tumor cells, including CXCL12 and HMGB1, resulting in robust infiltration of neutrophils into the tumor.

18. nitration on Tyr7 under inflammatory conditions is a novel natural posttranslational regulatory mechanism of CXCL12 which may downregulate the CXCR4-mediated inflammatory and tumor-promoting activities of CXCL12

19. SDF-1 is secreted shortly after UPEC infection initiating immune cell accumulation.

20. The data suggest that SDF-1beta provides synergistic effects supporting BMP-2-induced, BMSC-mediated bone formation and appears suitable for optimization of bone augmentation in combination therapy protocols.

Xenopus laevis Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. These findings support the conservation of sdf-1alpha signaling in vertebrate somite morphogenesis; however, the precise mechanism by which this signaling pathway influences somite morphogenesis is different between the fish and the frog.

2. expression patterns of xSDF-1a, xCXCR4, and xCXCR7 during gastrulation; results suggest SDF-1 signaling supports migration of the mesendoderm cell cohort toward the animal pole and that activin/nodal signaling acts as a regulator of the expression of xSDF-1a and xCXCR4, but not xCXCR7

3. SDF-1/CXCR4 chemokine signaling is involved in the migration and survival or in the differentiation of PGCs in Xenopus

4. A significant increase of stromal cell-derived factor-1alpha and CXCR4 was observed in protein extracts of idiopathic inflammatory myopathies in comparison with normal controls.

5. SDF-1 signaling is necessary for migrations of massive numbers of cells during gastrulation.

Pig (Porcine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. Polymorphisms in CXCL12 are significantly associated with immunological traits in Landrace piglets and have potential application value for marker-assisted selection of pig breeding with disease resistance.

2. The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1/CXCR4 axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.

Cow (Bovine) Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. Findings indicate that stromal fibroblasts within mammary glands with mastitis contribute to EMT and inflammatory responses of epithelial cells through the secretion of SDF-1, which could result in the inflammation spread and fibrosis within mammary gland.

2. There is a potential link between follicular SDF1/CXCR4 activation and the regulation of ovulation-related genes in cows and horses.

3. Polymorphism of intron 2 of the SDF1 gene in Galloway, Hereford, and Russian Black Pied cattle

Zebrafish Chemokine (C-X-C Motif) Ligand 12 (CXCL12) interaction partners

1. Cxcl12 and Myc facilitate glycolysis to promote fast migratory responses during development and repair during kidney injury and development

2. snail1b expression is initiated by chemokines first encountered by leading primordium cells and its expression plays a crucial role in initiating collective migration of the posterior lateral line primordium.

3. Study demonstrates that forced expression of Sdf1a in the fish embryo during early development is an effective strategy to disrupt primordial germ cell migration and produce large populations of infertile fish.

4. miR-126a directs lymphatic endothelial cell sprouting and extension by interacting with Cxcl12a-mediated chemokine signaling and Vegfc-Flt4 signal axis.

5. filopodia distribution and their dynamics are dictated by the gradient of the chemokine Cxcl12a.

6. Our data show that elevated concentrations of circulating CXCL12a in pulmonary hypertension predicted poorer survival

7. SDF1a directly controls the migration of both leading and trailing edges of a tissue through the activation of two independent receptors, CXCR4b and CXCR7.

8. Prospective isolation and culture of sdf1(DsRed) perivascular cells demonstrated properties consistent with mesenchymal stem cells.

9. Study shows that the primordium generates an attractant gradient across itself by sequestering Sdf1a protein in its rear via Cxcr7-mediated chemokine uptake. This self-generated attractant gradient, combined with the route information provided by the stripe of sdf1a-expressing cells, then provides directional guidance to the migrating primordium.

10. gata4 gene regulates sdf1a levels during early embryogenesis

11. These findings suggest an "attractive path" model in which migrating cells closely follow a dynamic SDF1a source that is refined on a transcript and protein level by miR-430 and Cxcr7b, respectively.

12. sdf-1 expression and function in the adult zebrafish have important similarities to mammals

13. Expression of Cxcl12 and Cxclr4 in radial glial cells of the adult zebrafish brain supports important roles for the Cxcl12/Cxcr4 pair in brain development and functioning.

14. A single amino acid exchange switches the relative affinity of the Cxcl12 ligands for one of the duplicated Cxcr4 receptors, thereby determining the functional specialization of each chemokine that elicits a distinct function in a distinct process.

15. we demonstrate that miR-430-mediated regulation of endogenous sdf1a and cxcr7b facilitates dynamic expression of sdf1a by clearing its mRNA from previous expression domains.

16. Study suggest that the Cxcl12a-Cxcr4b ligand-receptor pair are involved in the migration of GnRH3 neurons in zebrafish, and are therefore crucial for the development of this system.

17. A trail of SDF1-like chemokine encoded by the sdf1a gene is present along the pathway of the lateral line primordium. Both the formation and the innervation of this system depend on the SDF1-CXCR4 system

18. SDF1/CXCR4-mediated cell migration is preferentially associated with movement along the anteroposterior axis of the animal

19. SDF-1/CXCR4 signaling is important for guiding retinal ganglion cell axons within the retina to the optic stalk to exit the retina.

20. Sdf1a/Cxcr4a plays a critical role in fin regeneration and more precisely in epidermal cell proliferation, an important process for blastema formation