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anti-Human DISC1 Antibodies:
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Human Polyclonal DISC1 Primary Antibody for IHC - ABIN965998
Millar, Wilson-Annan, Anderson, Christie, Taylor, Semple, Devon, St Clair, Muir, Blackwood, Porteous: Disruption of two novel genes by a translocation co-segregating with schizophrenia. in Human molecular genetics 2000
Show all 5 Pubmed References
Human Polyclonal DISC1 Primary Antibody for ICC, ELISA - ABIN1002211
Morris, Kandpal, Ma, Austin: DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. in Human molecular genetics 2003
Show all 4 Pubmed References
Human Polyclonal DISC1 Primary Antibody for ELISA, WB - ABIN1002212
Taya, Shinoda, Tsuboi, Asaki, Nagai, Hikita, Kuroda, Kuroda, Shimizu, Hirotsune, Iwamatsu, Kaibuchi: DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Show all 4 Pubmed References
Polyclonal DISC1 Primary Antibody for IHC (p), WB - ABIN540418
Brandon, Handford, Schurov, Rain, Pelling, Duran-Jimeniz, Camargo, Oliver, Beher, Shearman, Whiting: Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders. in Molecular and cellular neurosciences 2004
Show all 3 Pubmed References
Polyclonal DISC1 Primary Antibody for IHC (fro), IHC (p) - ABIN540381
Ozeki, Tomoda, Kleiderlein, Kamiya, Bord, Fujii, Okawa, Yamada, Hatten, Snyder, Ross, Sawa: Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. in Proceedings of the National Academy of Sciences of the United States of America 2003
Show all 2 Pubmed References
Mouse (Murine) Polyclonal DISC1 Primary Antibody for ICC, IHC (fro) - ABIN258331
El-Hassar, Simen, Duque, Patel, Kaczmarek, Arnsten, Yeckel: Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels. in Biological psychiatry 2014
A Disc1 peptide binds to GSK3beta, and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin-mediated Wnt signaling and inhibiting GSK3beta activity.
Disc1 and nrg1 (show NRG1 Antibodies) function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 Antibodies)-expressing precursor cells.
Disc1 functions in the transcriptional repression of foxd3 (show FOXD3 Antibodies) and sox10 (show SOX10 Antibodies), thus mediating cranial neural crest cell migration and differentiation.
The nervous system developmental pathway is a potential pathogenesis of sporadic amyotrophic lateral sclerosis, among them, the polymorphism of rs3737597 in DISC1 might play some roles.
meta-analysis analyzed the association between DISC1 SNPs rs3738401 and rs821616 with schizophrenia. We found that rs3738401 did not show association with schizophrenia in the Caucasian, Asian or Japanese subgroups
DISC1 affects glioblastoma cell development via mitochondria dynamics partly by down regulation of Drp1 (show CRMP1 Antibodies).
In combination with molecular modeling, data support predictions regarding the three-dimensional fold of a DISC1 segment as well as its steric arrangement in complex with a llama heavy chain antibody.
Authors found that three pathways that include the homologs of Drosophila Dys (show IKBKAP Antibodies), Trio (show TRIO Antibodies), and Shot (show SHOX2 Antibodies) were downregulated by introducing a C-terminal truncated mutant DISC1.
disrupting DISC1/Ndel1 (show NDEL1 Antibodies) complex formation prolongs mitotic length and interferes with cell-cycle progression in human cells, and it causes cell-cycle deficits of radial glial cells in the embryonic mouse cortex and human forebrain organoids
Study reports sex-specific influence of common disrupted-in-schizophrenia-1 variants on volumes of the basal ganglia, the amygdala and on the cortical surface area.
Study found a significant association between the DISC1 gene polymorphism rs6675281 alone, and the combination of rs6675281 and rs821616, and differences in long-term cortical thickness growth in patients with a first-episode of psychosis; and observed an overall difference in cortical thickness, as well as heightened disparities in the frontal and temporal brain regions.
HTT (show HTT Antibodies) forms a ternary protein complex with the scaffolding protein DISC1 and cAMP-degrading phosphodiesterase 4 (PDE4 (show PDE4A Antibodies)) to regulate PDE4 (show PDE4A Antibodies) activity.
This theme highlights the importance of understanding precisely how DISC1 can regulate intracellular trafficking, and suggests that a novel approach to the treatment of psychiatric disorders could be provided by targeting this protein and the trafficking machinery with which it interacts.
Mutant DISC1 revealed increased spontaneous firing of Purkinje cells and impaired cognitive and social behaviors.
This study shown the disc1 mutation and environment effect the neuronal activity, long-range synchrony and directed interactions within hippocampal-prefrontal networks are impaired at both developmental stages in mice.
DISC1 in association with SNPH (show SNPH Antibodies) is a component of a modulatory complex that determines mitochondrial anchoring in response to neuronal activation.
the existence of abnormal synaptic transmission and plasticity in hippocampal network may disrupt declarative information processing and contribute to recognition deficits in DISC1 L100P mutant mice.
Co-disruption of DISC1 and NRG1 (show NRG1 Antibodies), indicative of epistasis, evoked an impairment in sociability and enhanced self-grooming, accompanied by changes in hypothalamic oxytocin/vasopressin (show AVP Antibodies) gene expression in a mouse schizophrenia model.
the 100P mutation in Disc1 prevents expression of parvalbumin (show PVALB Antibodies) by a normally sized cohort of interneurons and altering Disc1 function in cortical excitatory neurons indirectly affects parvalbumin (show PVALB Antibodies) expression by cortical interneurons, perhaps as a result of altered functional input from the excitatory neurons.
mutant DISC1 diminished the capacity of astrocytes to support dendritic and synaptic maturation in co-cultured neurons
abnormality in hippocampal activity at the goal zone during the task may underlie the learning deficit observed in the DISC1 mutant mice.
Missense mutation in DISC1 C-terminal coiled-coil has GSK3beta signaling and sex-dependent behavioral effects in mice
Systematic investigation suggests that DISC1 is present in several cellular compartments, including synapses, where it interacts with a wider molecular network to mediate cellular and synaptic function.
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
disrupted in schizophrenia 1 protein
, disrupted in schizophrenia 1
, disrupted in schizophrenia 1 homolog