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This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
collapsin response mediator protein hCRMP-2
, dihydropyrimidinase-related protein 2
, unc-33-like phosphoprotein 2
, collapsin response mediator protein 2
, neural-specific protein NSP60
, turned on after division 64
, dihydropyrimidinase-like 2
, turned on after division 64 kDa protein
, turned on after division, 64 kDa protein
, collapsin response mediator protein CRMP-62
, collapsin response mediator protein-2A
, dihydropyrimidinase-related protein 2-like