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The findings reveal a critical role for CRMP2 in neuronal plasticity, neural function and behavioral modulation in mice.
Results suggested that crmp2 is a target of miR (show MLXIP Proteins)-181c and that the abnormally low expression of miR (show MLXIP Proteins)-181c in the hippocampus of SAMP8 mice could lead to an increase of the crmp2 protein level in Alzheimer's disease mice, which might potentially play a role in the pathogenesis of Alzheimer's disease
These results suggest a correlation between CRMP2 phosphorylation and AD pathophysiology, and indicate the effectiveness of pioglitazone treatment at the pre-Abeta (show APP Proteins) accumulation stage in AD model mice.
We generated CRMP2 gene-deficient (crmp2(-/-) ) mice. The crmp2(-/-) mice showed irregular development of dendritic spines in cortical neurons. The level of CRMP1 (show CRMP1 Proteins) was increased in crmp2(-/-) , but the level of CRMP2 was not altered in crmp1 (show CRMP1 Proteins)(-/-).The phenotypic defects had no genetic interaction between crmp1 (show CRMP1 Proteins) and crmp2.
study implies that dysregulation of CRMP2 may be involved in pathophysiology of neuropsychiatric disorders
we demonstrate that Cdk5 (show CDK5 Proteins) phosphorylates collapsin response mediator protein 2 (CRMP2) in the dendritic spines of cultured hippocampal neurons and in vivo in the mouse brain. When we eliminated CRMP2 phosphorylation in CRMP2(KI/KI (show AXIN1 Proteins)) mice, the densities of dendritic spines significantly decreased in hippocampal CA1 (show CA1 Proteins) pyramidal neurons in the mouse brain.
We propose that CRMP2 could contribute to long-lasting synaptic plasticity.
This study shows that in young adult mice, motor and sensory functions lost by SCI can be recovered with a single genetic mutation to inhibit CRMP2 phosphorylation
Study showed that axon degeneration is an early and dominant feature in dopaminergic neurons treated with 1-methyl-4-phenylpyridiniumion (MPP+), and that the Akt/GSK-3beta/CRMP-2 pathway is involved in axon degeneration induced by MPP+
Clear differences in CRMP2 protein abundance and degradation product/short isoform were observed between ischemic core and penumbra (show TSPAN33 Proteins) and also compared to the contralateral healthy tissues after PACAP38 (show ADCYAP1 Proteins) or saline treatment.
These data identify a novel oncogenic mechanism where CDK5 (show CDK5 Proteins) activation induces CRMP2A phosphorylation in the nuclei of tumour cells
polymorphisms of the DPYSL2 gene in humans may be associated with the development of schizophrenia.
Functional variants in DPYSL2 sequence increase risk of schizophrenia and suggest a link to mTOR (show FRAP1 Proteins) signaling
Changes for CRMP2, TCP1epsilon, TPM2 (show TPM2 Proteins) and 14-3-3gamma (show YWHAG Proteins) were confirmed in experimental tumors and in a series of 28 human SI-NETs.
Reduced CRMP2 expression and elevated expression of nuclear phosphorylated CRMP2 may be associated with breast cancer progression.
Levels of total GSK3 were decreased in the Huntington disease (show HTT Proteins)-affected frontal cortex and this correlated with decreased phosphorylated CRMP2.
High dihydropyrimidinase-related protein 2 expression is associated with lung cancer.
genetic variants in DPYSL2 may play a role in susceptibility to alcohol dependence.
A specific and reversible intermolecular Cys (show DNAJC5 Proteins)-504-Cys (show DNAJC5 Proteins)-504 dithiol-disulfide switch in homotetrameric CRMP2 determines two conformations of the quaternary CRMP2 complex that controls axonal outgrowth and thus neuronal development.
CRMP-2-dependent regulation of ROCK II (show ROCK2 Proteins) activity is mediated through interaction of the CRMP-2L N terminus with the ROCK II (show ROCK2 Proteins) catalytic domain as well as by GSK3-dependent phosphorylation of CRMP-2.
phosphorylation of Dpysl2 and Dpysl3 (show DPYSL3 Proteins) by Cyclin-dependent kinase 5 (show CDK5 Proteins) and dual-specificity tyrosine-phosphorylated and regulated kinase 2 is required for correct positioning of CaP motor neurons in the zebrafish spinal cord
These results suggest that the phosphorylation of Dpysl2 and Dpysl3 (show DPYSL3 Proteins) by Cdk5 (show CDK5 Proteins) and DYRK2 (show DYRK2 Proteins) is required for the proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish embryos.
From 20 somites through 30 hpf CRMP2 is expressed in the dorsal rostral cluster of the telencephalon, the ventral rostral cluster of the diencephalon, the ventral caudal cluster of the mesencephalon, and the hindbrain clusters.
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
collapsin response mediator protein hCRMP-2
, dihydropyrimidinase-related protein 2
, unc-33-like phosphoprotein 2
, collapsin response mediator protein 2
, neural-specific protein NSP60
, turned on after division 64
, dihydropyrimidinase-like 2
, turned on after division 64 kDa protein
, turned on after division, 64 kDa protein
, collapsin response mediator protein CRMP-62
, collapsin response mediator protein-2A
, dihydropyrimidinase-related protein 2-like