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Low SEMA3D expression is associated with colorectal cancer.
Novel mutation in SEMA3D segregates with the complete phenotype with variable expressivity in two pedigrees with autosomal dominant familial Meniere's disease.
Data show significant increases in semaphorin3C, 3D and their receptor neuropilin-2 (show NRP2 Proteins) in degenerate samples which were shown to contain nerves and blood vessels, compared to non-degenerate samples without nerves and blood vessels.
CTNNA3 (show CTNNA3 Proteins) and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies
Functional loss of semaphorin 3C (show SEMA3C Proteins) and/or semaphorin 3D and their epistatic interaction with ret (show RET Proteins) are critical to Hirschsprung disease liability.
Semaphorin 3d requires neuropilin 1 (show NRP1 Proteins) or PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins), whereas semaphorin 3e (show SEMA3E Proteins) requires plexin D1 (show PLXND1 Proteins) in directing endothelial motility.
In the absence of Sema3d, endothelial tubes form in a region that is normally avascular
in this study we have analyzed three aminoacidic substitutions, A131T-SEMA3A (show SEMA3A Proteins), S598G-SEMA3A (show SEMA3A Proteins) and E198K-SEMA3D. These variants result in an increase of SEMA (show SEMA3B Proteins) proteins levels in the HSCR (show EDNRB Proteins) colon tissue.
This study provided strong evidence that SEMA3D confers susceptibility to schizophrenia, which could contribute to the neurodevelopmental impairments in the disorder.
Sema3D inhibits tumor development from MDA-MB-231 and MDA-MB-435 cancer cells. It inhibits tumor angiogenesis in all of the formed tumors.
Authors did not find evidence for genetic interaction between Ret (show RET Proteins) and Sema3d affecting survival, presence of myenteric plexus or intestine transcriptome.
Data indicate that annexin A2 (AnxA2 (show ANXA2 Proteins)) regulates the secretion of semaphorin 3D (Sema3D) from pancreatic ductal adenocarcinoma (PDA) cells.
Semaphorin 3d requires neuropilin 1 (show NRP1 Proteins) or PI3K/Akt (show AKT1 Proteins), whereas semaphorin 3e (show SEMA3E Proteins) requires plexin D1 (show PLXND1 Proteins) in directing endothelial motility.
Two proepicardial markers (Scleraxis and Semaphorin3D) were identified that genetically delineate heretofore uncharacterized proepicardial subcompartments.
Sema (show SEMA3B Proteins) 3D and Sema (show SEMA3B Proteins) 3F genes are overlappingly and distinctly expressed in the developing parathyroid and thymus, respectively, and they might play roles in the interactions between these organs and surrounding tissues
Sema3d regulates collective endothelial cell migration in zebrafish through two separate mechanisms. Mesenchymal Sema3d guides outgrowth of the common cardinal (show CARD8 Proteins) vein via repulsion and signals through PlexinD1.
Hapln1a (show HAPLN1 Proteins)-ECM (show MMRN1 Proteins) stabilizes the secreted growth factor (show WNT2 Proteins) Semaphorin3d (Sema3d), which has been independently shown to mediate Cx43 (show GJA1 Proteins) dependent phenotypes during regeneration.
Sema3d functions in a common molecular pathway with Cx43 (show GJA1 Proteins) in cell proliferation and joint formation
We investigated the role of Semaphorin3D (Sema3D) in the formation of the early axon pathways in the zebrafish CNS.
Data show that Hedgehog (show SHH Proteins) signaling is required for commissure formation, glial bridge formation, and the restricted expression of the guidance molecules slit1a, slit2 (show SLIT2 Proteins), slit3 (show SLIT3 Proteins) and sema3d.
proper balance of Sema3d is needed at the midline for the progression of retinal ganglion cell axons from the chiasm midline into the contralateral optic tract
We propose that a population of sema3D-dependent neural crest cells follow a novel migratory pathway, perhaps toward nrp1A-expressing LPM, and serve as an important early source of cardiomyocytes in the primary heart field.
Sema3d knockdown reduces markers of migratory neural crest cell (NCC (show SLC12A3 Proteins)) and disrupts NCC (show SLC12A3 Proteins)-derived tissues.
Sema3D acts in concert with Nrp1a to guide neurons on the left side of the brain to innervate the target nucleus differently than those on the right side.
We show that Semaphorin3D (Sema3D), a classic repulsive molecule, promotes fasciculation by regulating L1 CAM levels and axon-axon interactions rather than by creating a repulsive surround.
Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity).
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
, semaphorin 3D
, collapsin 2
, semaphorin, homolog of the avian Sema3D
, sema Z2
, semaphorin 2