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anti-Human SMURF1 Antibodies:
anti-Mouse (Murine) SMURF1 Antibodies:
anti-Rat (Rattus) SMURF1 Antibodies:
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Human Polyclonal SMURF1 Primary Antibody for IHC (p), WB - ABIN388828
Tajima, Goto, Yoshida, Shinomiya, Sekimoto, Yoneda, Miyazono, Imamura: Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7. in The Journal of biological chemistry 2003
Show all 8 Pubmed References
Human Monoclonal SMURF1 Primary Antibody for IF, IHC (p) - ABIN566098
Murakami, Mathew, Huang, Farahani, Peng, Olson, Etlinger: Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension. in Experimental biology and medicine (Maywood, N.J.) 2010
Show all 2 Pubmed References
Human Polyclonal SMURF1 Primary Antibody for IHC (p), WB - ABIN388829
Suzuki, Murakami, Fukuchi, Shimanuki, Shikauchi, Imamura, Miyazono: Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane. in The Journal of biological chemistry 2002
Show all 5 Pubmed References
Human Polyclonal SMURF1 Primary Antibody for IHC (p), ELISA - ABIN542766
Schwamborn, Khazaei, Püschel: The interaction of mPar3 with the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity. in The Journal of biological chemistry 2007
Human Polyclonal SMURF1 Primary Antibody for IHC (p), ELISA - ABIN542767
Kaneki, Guo, Chen, Yao, Schwarz, Zhang, Boyce, Xing: Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts. in The Journal of biological chemistry 2006
Nedd8 binding to Smurf plays important roles in the regulation of cell migration and the BMP and TGFbeta signaling pathways.
Expression of Smurf1 was increased with WHO grade and was consistent with poor prognosis of gliomas.
Smurf1 interacts with and targets Securin, an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation.
Smurf1 overexpression decreases USP25 protein turnover, and the E3 ligase enzymatic activity of Smurf1 is required for USP25 degradation.
SMURF1 can be potentially used as a clinical biomarker and target for novel treatment of human GC.
Uev1A appears to be involved in the BMP signaling pathway in which it collaborates with a ubiquitin E3 ligase Smurf1 to promote Smad1 degradation in a Ubc13-independent manner.
High smurf1 expression is associated with neoplasms.
activation of AMPK upregulated Smad6 and Smurf1 and thereby enhanced their interactions, resulting in its proteosome-dependent degradation of ALK2.
we propose that the PKA-Smurf1-PIPKIgamma pathway has an important role in pulmonary tumorigenesis and imposes substantial clinical impact on development of novel diagnostic markers and therapeutic targets for lung cancer treatment.
SMURF1 is increased in patients with pulmonary arterial hypertension
Data suggest that SMURF1 is required for S phase progression; SMURF1 promotes ubiquitination-dependent degradation of WEE1; these functions of SMURF1 appear to be linked and may be important in cell proliferation and tumorigenesis. (SMURF1 = SMAD specific E3 ubiquitin protein ligase 1; WEE1 = wee 1 homolog [S pombe] protein)
Taken together, our study for the first time clarified that the E3 ligase Smurf1 regulates USP5 protein stability and USP5-mediated TNF-alpha production through the ubiquitin proteasome pathway.
results reveal the regulatory circuit between RUNX2 and SMURF1 controls RUNX2 expression and regulates odntoblastic differentiation in hDPSCs.
EGF/Smurf1 inhibits Wnt/beta-catenin-induced osteogenic differentiation and that Smurf1 downregulates Wnt/b-catenin signaling by enhancing proteasomal degradation of beta-catenin.
a model that CD166 regulates MCAM through a signaling flow from activation of PI3K/AKT and c-Raf/MEK/ERK signaling to the inhibition of potential MCAM ubiquitin E3 ligases, betaTrCP and Smurf1.
SND1 promoted expression of the E3 ubiquitin ligase Smurf1, leading to RhoA ubiquitination and degradation.
NF-kappaB bind to the -411 to -420 region of the SMURF1 promoter and plays an essential role in the expression of SMURF1.
Smurf1 determines cell apoptosis rates downstream of DNA damage-induced ATR/Chk1 signalling by promoting degradation of RhoB.
The role of SMURF1 and inhibition of BMP signaling in maintaining a CSC-like population was confirmed by the loss of a CD44(high) expressing.
Results suggest that elevated transcription and expression levels of ubiquitin ligase E3s WWP1, Smurf1 and Smurf2 genes may be the mechanisms of occurrence, development and metastasis of prostate cancer.
Data demonstrate that Smurf1 and Smurf2 have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.
In Xenopus embryos, the BMP pathway is a major physiological target of Smurf1. We propose that in normal development Smurf1 cooperates with secreted BMP antagonists to limit BMP signaling in dorsal ectoderm.
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.
Smad ubiquitination regulatory factor 1
, E3 ubiquitin-protein ligase SMURF1
, SMAD specific E3 ubiquitin protein ligase 1
, e3 ubiquitin-protein ligase SMURF1-like
, E3 ubiquitin ligase SMURF1
, SMAD-specific E3 ubiquitin-protein ligase 1
, Smad-specific E3 ubiquitin ligase 1
, SMAD ubiquitination regulatory factor 1