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This study presents the atomic model of rabbit TRPV2 in its putative desensitized state, as determined by cryo-EM at a nominal resolution of approximately 4 A.
TRPV2 expression was inversely correlated with CRP (show CRP Proteins) and TpI (show TPI1 Proteins) and directly correlated with serum IGF-1 (show IGF1 Proteins). We assume that peripheral TRPV2 downregulation occurs concomitantly with the accumulation of TRPV2-white blood cells in the peri (show PLIN1 Proteins)-infarct zone. TRPV2 may thus represent a novel target for treatment in the acute phase after MI.
the expression of transient receptor potential vanilloid-1 (TRPV1 (show TRPV1 Proteins)), transient receptor potential vanilloid-2 (TRPV2) and transient receptor potential vanilloid-3 (TRPV3 (show TRPV3 Proteins)) channels in native human odontoblasts, was examined.
High TRPV2 expression is associated with breast cancer.
both TRPV2 and TRPV4 are involved in migration of human cardiac c-kit(+) progenitor cells.
The results of the study show that polymorphism of TRPV2 influenced the susceptibility to FM.
CGRP (show S100A12 Proteins)- and TRPV2-containing trigeminal neurons probably innervate the paranasal sinus mucosae, and project into spinal and principal trigeminal sensory nuclei.
transient receptor potential vanilloid 2 is an intracellular Ca(2 (show CA2 Proteins)+)-permeable transient receptor potential vanilloid channel upregulated by nerve growth factor via the mitogen-activated protein kinase (show MAPK1 Proteins) signaling pathway to augment neurite outgrowth.
Using multiple sequence alignments as source for evolutionary, bioinformatics and statistical analysis, we have analyzed the evolutionary profiles for TRPV1 (show TRPV1 Proteins), TRPV2, TRPV3 (show TRPV3 Proteins) and TRPV4 (show TRPV4 Proteins)
There appears to be TRPV1 (show TRPV1 Proteins)- or TRPV2-IR sympathetic pathway in the human stellate ganglion and spinal cord.
This study evaluated the role of Trpv2 in arthritis and the pharmacological effects of Trpv2 agonists.
data suggest that knockout of the TRPV2 channel may attenuate macrophage-dependent pro-inflammatory processes and result in better cardiac recovery. TRPV2 may thus represent a novel therapeutic target for treatment of patients undergoing an acute MI
We conclude that TRPV2 function, as a stretch-activated channel, regulates the development of cardiomyocyte hypertrophy in response to increased afterload.
These findings suggest that TRPV2 activation via actin reorganization induced by Gq and G12 (show TCF3 Proteins)/13 signaling is involved in LPI (show Slc7a7 Proteins)-stimulated GLP-1 (show GCG Proteins) secretion in enteroendocrine L cells.
Expression of TRPV2 was dramatically increased during the differentiation of brown adipocytes. TRPV2 might be involved in the modulation of brown adipocyte differentiation partially via a calcineurin pathway.
TRPV2 channels are demonstrated here to play a key role in cation influx and dysregulation in dystrophin (show DMD Proteins) deficient cardiomyocytes, enhanced in stretching conditions
TRPV2KO mice show cold intolerance and impaired BAT (show BAAT Proteins) thermogenesis.
We conclude that TRPV2 is involved in osmosensation in skeletal muscle fibres, acting in concert with P-SPAK (show STK39 Proteins)-activated NKCC1 (show SLC12A2 Proteins)
TRPV2-knockout mice have impaired cardiac functional response to exercise.
TRPV2 channels play a predominant role in fluid flow mechanosensitivity over that of TRPC1 (show TRPC1 Proteins) and TRP (show TYRP1 Proteins) melastatin (show TRPM1 Proteins) (TRPM) 7 (show TRPM7 Proteins).
TRPV2 is involved in a stretch-activated calcium influx pathway in dystrophic cardiomyopathy, contributing to the defective cellular Ca2 (show CA2 Proteins)+ handling in this disease.
This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat.
transient receptor potential cation channel, subfamily V, member 2
, transient receptor potential cation channel subfamily V member 2
, transient receptor potential cation channel subfamily V member 2-like
, osm-9-like TRP channel 2
, vanilloid receptor-like protein 1
, stretch-activated channel 2B
, growth factor regulated channel
, growth factor-regulated calcium channel