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show that MAP6 (show MAP6 Antibodies) proteins interact directly with both Tctex1 and the C-terminus of Cav2.2 (show CACNA1B Antibodies)/N-type calcium channels.
activin receptor IIB (show ACVR2B Antibodies) as a novel DYNLT1 ligand and suggest that DYNLT1 functions as a molecular dimerization engine bringing together two receptor monomers in the cytoplasmic side of the membrane.
Dynlt1 modulates orexin (show OX Antibodies) signaling by regulating OX1R (show HCRTR1 Antibodies)
Targeted disruption of Tctex-1 by RNA interference significantly impairs bone resorption capacity and mislocalizes Rab3D (show RAB3D Antibodies) vesicles in osteoclasts.
Results identify a regulatory region of the Tctex-1 gene that is capable of directing transgenic expression of green fluorescent protein (GFP) reporter that recapitulates the spatial and temporal expression pattern of endogenous Tctex-1.
Association with Tctex-1 and, hence, with the dynein motor complex may offer an explanation for how poliovirus hijacks the cellular transport machinery to retrogradely ascend along the axon to the neuronal cell body.
Tctex-1 is a novel effector of Gbetagamma, and the Gbetagamma-Tctex-1 complex plays a key role in the dynein-independent function of Tctex-1 in regulating neurite outgrowth in primary hippocampal neurons.
Thus, Lfc (show ARHGEF2 Antibodies) and Tctex-1 interact to regulate cortical neurogenesis, potentially by regulating mitotic spindle orientation.
Tctex1 overexpression promoted autophagy lysosome fusion and effectively degraded alpha-synuclein with increased cell activity
Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination.
results support a model in which phospho(T94)Tctex-1-regulated actin polymerization and periciliary endocytosis play an active role in orchestrating the initial phase of ciliary resorption
DYNLT1 interacts with nucleoporins and plays a role in the dysregulation of gene expression and induction of hematopoietic cell proliferation by the leukemogenic nucleoporin (show AGFG2 Antibodies) fusion, NUP98 (show NUP98 Antibodies)-HOXA9 (show HOXA9 Antibodies)
Study reports a defect in the expression of DYNLT1 in the germ cells of infertile human males and implicates DYNLT1 in spermatogonial cell division and differentiation.
The results implicate MTs (show TIMM8A Antibodies)/DYNLT1 as drivers of Vpr nuclear import and HIV infection, with important therapeutic implications.
Data suggest that both microtubule-associated DYNLT (dynein light chain Tctex-type 1) and cytoplasmic DYNLT (dynein 1 intermediate chain 2 DYNC1LI2 (show DYNC1LI2 Antibodies)) are equally able to bind to small GTPases Rab3D (Rab3d (show RAB3D Antibodies) GTPase (show RACGAP1 Antibodies)) and RagA (Ras-related GTP binding A (show RRAGA Antibodies)).
Reveal a dynein independent role of Tctex-1 at the kinetochore to enhance the stability of kinetochore-microtubule attachment.
DYNLT1 is enriched at focal concentrations of CT850 on the chlamydial inclusion membrane that are known to interact with dynein and microtubules.
Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005
dynein, light chain, Tctex-type 1
, dynein, light chain, Tctex-type 1 a
, t-complex testis expressed 1
, Tctex1-related dynein light chain
, dynein light chain Tctex-type 1
, T-complex testis-specific protein 1 homolog
, activator of G-protein signaling 2
, T-complex testis-specific protein 1
, dynein light chain Tctex-type 1D
, t-complex-associated-testis-expressed 1-like 1