DYNLT1 antibody

Catalog No. ABIN7113673

This Rabbit Polyclonal antibody specifically detects DYNLT1 in WB, IP, IHC and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for DYNLT1 antibody (ABIN7113673)

Target: DYNLT1 (Dynein, Light Chain, Tctex-Type 1 (DYNLT1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYNLT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA

Product Details anti-DYNLT1 Antibody

Purpose: DYNLT1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: dynein, light chain, Tctex-type 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for DYNLT1

Target: DYNLT1 (Dynein, Light Chain, Tctex-Type 1 (DYNLT1))

Alternative Name: DYNLT1

Background:

Synonyms: Dynein light chain Tctex-type 1|Protein CW-1|T-complex testis-specific protein 1 homolog|DYNLT1|TCTEL1|TCTEX-1|TCTEX1

Background: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein. Plays a role in neuronal morphogenesis, the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling, the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis, inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation(By similarity).

Molecular Weight: 12 kDa

Gene ID: 6993

UniProt: P63172

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling