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Data suggest that a hetero-multimer complex forms between light-activated rhodopsin (show RHO Proteins) and light-activated heterotrimeric transducin (T-alpha-1, Gnb1 (show GNB1 Proteins), Gngt1 (show GNGT1 Proteins)); the stoichiometry is 1:1 rhodopsin:transducin. The complex appears to form on native rod outer segment membranes upon light activation.
These results indicated that efficient Gt activation by rhodopsin (show RHO Proteins), resulting from an optimized active state of rhodopsin (show RHO Proteins), is one of the causes of the high amplification efficiency of rods.
These data suggest that some truncating GNAT1 variants can indeed cause a recessive, mild, late-onset retinal degeneration in human beings rather than just stationary night-blindness as reported previously.
Three candidate tumor-suppressor genes, SEMA3B (show SEMA3B Proteins), AXUD1 (show CSRNP1 Proteins) and GNAT1 may be involved in oral squamous cell carcinoma.
These data suggest that a homozygous missense mutation in GNAT1 is associated with autosomal recessive stationary night blindness.
Expression of GNAT1 gene is down-regulated or absent in nasopharyngeal carcinoma tissues.
Data suggest light reduces oxygen consumption rate (OCR) of retina; light does not affect OCR in retinas of Gnat1-/- knockout mice (phototransduction disabled). Light reduces cGMP in retina; light does not alter cGMP in Gnat1-/- plus Gnat2 (show GNAT2 Proteins)-/- retina.
Biochemical changes, including reduced transducin protein levels and enhanced transducin GTPase (show RACGAP1 Proteins) activity, explain the shift in light intensity threshold for Galphat1 translocation in Rs1 (show RS1 Proteins)-knockout mice.
The results from shaker1 and whirler mice suggest that defective transducin translocation may be functionally related to light-induced degeneration.
ectopically expressed cTalpha (show PCYT1A Proteins) 1) forms a heterotrimeric complex with rod Gbeta (show SUCLG2 Proteins)(1)gamma(1), and substitutes equally for rTalpha in generating photoresponses initiated by either rhodopsin (show RHO Proteins) or S-cone opsin (show RHO Proteins)
Oligomerization incompetent retinal degeneration slow (show PRPH2 Proteins) is associated with mislocalization of cone opsins and cone transducin.
Data show that visual responses in TKO (show MRPS12 Proteins) mice extend beyond the retina to encompass the lateral margins of the lateral geniculate nucleus and components of the visual cortex.
Thus our results showed that IRD1 and IRD2 mice harbor a nonsense mutation in the Gnat1 gene, resulting in the absence or suppressed expression of the Tralpha protein, which is the likely cause of rod dysfunction in both mutants.
alpha-transducin can function in taste receptor cells and transduce some taste cell responses
data suggest that phosducin (show PDC Proteins) action is based on the reduction of transducin affinity to the membranes of rod outer segments, achieved by keeping the transducin beta gamma subunits apart from the alpha subunit (show POLG Proteins).
Alpha-transducin played no role in regulating adaptive response to light. Degeneration does not require transducin-mediated signaling.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
guanine nucleotide-binding protein G(t) subunit alpha-1
, rod-type transducin alpha subunit
, guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
, guanine nucleotide binding protein, alpha transducing activity polypeptide 1
, guanine nucleotide-binding protein G(t) subunit alpha-1-like
, transducin alpha-1 chain
, guanine nucleotide-binding protein G(T), alpha-1 subunit
, transducin, rod-specific
, guanine nucleotide binding protein (G protein), alpha transducing 1
, guanine nucleotide binding protein, alpha transducing 1
, Galpha t1
, rod transducin alpha subunit
, transducin alpha (rod)
, rod photoreceptor transducin alpha 1 subunit
, transducin alpha subunit GNAT1